Anti-PPP3CA Antibody (CAB1063)
- SKU:
- CAB1063
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-PPP3CA Antibody |
| 抗体コード: | CAB1063 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-511 of human PPP3CA (NP_001124163.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HeLa, SH-SY5Y, THP-1, A-549, Mouse brain, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-511 of human PPP3CA (NP_001124163.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSEP KAID PKLS TTDR VVKA VPFP PSHR LTAK EVFD NDGK PRVD ILKA HLMK EGRL EESV ALRI ITEG ASIL RQEK NLLD IDAP VTVC GDIH GQFF DLMK LFEV GGSP ANTR YLFL GDYV DRGY FSIE CVLY LWAL KILY PKTL FLLR GNHE CRHL TEYF TFKQ ECKI KYSE RVYD ACMD AFDC LPLA ALMN QQFL CVHG GLSP EINT LDDI RKLD RFKE PPAY GPMC DILW SDPL EDFG NEKT QEHF THNT VRGC SYFY SYPA VCEF LQHN NLLS ILRA HEAQ DAGY RMYR KSQT TGFP SLIT IFSA PNYL DVYN NKAA VLKY ENNV MNIR QFNC SPHP YWLP NFMD VFTW SLPF VGEK VTEM LVNV LNIC SDDE LGSE EDGF DGAT AAAR KEVI RNKI RAIG KMAR VFSV LREE SESV LTLK GLTP TGML PSGV LSGG KQTL QSAI KGFS PQHK ITSF EEAK GLDR INER MPPR RDAM PSDA NLNS INKA LTSE TNGT DSNG SNSS NIQ |
| 遺伝子ID: | 5530 |
| Uniprot: | Q08209 |
| セルラーロケーション: | Cell membrane, Nucleus, sarcolemma |
| 計算された分子量: | 31kDa/51kDa/52kDa/57kDa/58kDa |
| 観察された分子量: | 57kDa |
| 同義語: | PPP3CA, CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B |
| バックグラウンド: |
| UniProt Protein Function: | PPP3CA: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A alpha. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. Dephosphorylates HSPB1. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.. |
| UniProt Protein Details: | Protein type:Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16 Chromosomal Location of Human Ortholog: 4q24 Cellular Component: nucleoplasm; mitochondrion; cytoplasm; Z disc; cytosol; calcineurin complex; sarcolemma Molecular Function:calmodulin binding; protein dimerization activity; protein binding; enzyme binding; calmodulin-dependent protein phosphatase activity; protein heterodimerization activity; protein serine/threonine phosphatase activity; drug binding; calcium ion binding Biological Process: regulation of synaptic transmission; positive regulation of NFAT protein import into nucleus; T cell activation; response to amphetamine; skeletal muscle fiber development; protein amino acid dephosphorylation; negative regulation of insulin secretion; calcineurin-NFAT signaling pathway; transition between fast and slow fiber; dephosphorylation; protein import into nucleus; calcium ion transport; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to calcium ion; regulation of excitatory postsynaptic membrane potential; multicellular organismal response to stress; G1/S transition of mitotic cell cycle |
| UniProt Code: | Q08209 |
| NCBI GenInfo Identifier: | 1352673 |
| NCBI Gene ID: | 5530 |
| NCBI Accession: | Q08209.1 |
| UniProt Related Accession: | Q08209 |
| Molecular Weight: | 59kDa |
| NCBI Full Name: | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
| NCBI Synonym Full Names: | protein phosphatase 3 catalytic subunit alpha |
| NCBI Official Symbol: | PPP3CA |
| NCBI Official Synonym Symbols: | CALN; CCN1; CNA1; CALNA; IECEE; PPP2B; ACCIID; CALNA1; IECEE1 |
| NCBI Protein Information: | serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform |
| UniProt Synonym Protein Names: | CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform |
| UniProt Gene Name: | PPP3CA |
| UniProt Entry Name: | PP2BA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPP3CA antibody (CAB1063) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of HeLa cells using PPP3CA antibody (CAB1063). Blue: DAPI for nuclear staining. |