Anti-PPP2R1B Antibody (CAB6703)
- SKU:
- CAB6703
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PPP2R1B Antibody |
| 抗体コード: | CAB6703 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 468-667 of human PPP2R1B (NP_859050.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 468-667 of human PPP2R1B (NP_859050.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | YAIR EAAT NNLM KLVQ KFGT EWAQ NTIV PKVL VMAN DPNY LHRM TTLF CINA LSEA CGQE ITTK QMLP IVLK MAGD QVAN VRFN VAKS LQKI GPIL DTNA LQGE VKPV LQKL GQDE DMDV KYFA QEAI SVVA QRLR KLEF PVKD SGEP SVPR ADKN HFPR PTVP GEDM GKGP VYQL RGDT RDTL AQLG IAEL VHFS QSTD |
| 遺伝子ID: | 5519 |
| Uniprot: | P30154 |
| セルラーロケーション: | |
| 計算された分子量: | 52kDa/61kDa/66kDa/73kDa |
| 観察された分子量: | 65kDa |
| 同義語: | PPP2R1B, PP2A-Abeta, PR65B |
| バックグラウンド: | This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. |
| UniProt Protein Function: | PPP2R1B: The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Belongs to the phosphatase 2A regulatory subunit A family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 11q23.2 Cellular Component: lipid raft Molecular Function:protein binding Disease: Lung Cancer |
| NCBI Summary: | This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010] |
| UniProt Code: | P30154 |
| NCBI GenInfo Identifier: | 116241236 |
| NCBI Gene ID: | 5519 |
| NCBI Accession: | P30154.3 |
| UniProt Secondary Accession: | P30154,O75620, Q8NHV8, A8MY67, B0YJ69, B4DGQ6, B4DK91 B4DWW5, F8W8G1, |
| UniProt Related Accession: | P30154 |
| Molecular Weight: | 52,214 Da |
| NCBI Full Name: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
| NCBI Synonym Full Names: | protein phosphatase 2 scaffold subunit Abeta |
| NCBI Official Symbol: | PPP2R1B |
| NCBI Official Synonym Symbols: | PR65B; PP2A-Abeta |
| NCBI Protein Information: | serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform |
| UniProt Synonym Protein Names: | PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta |
| UniProt Gene Name: | PPP2R1B |
| UniProt Entry Name: | 2AAB_HUMAN |
 | Western blot analysis of extracts of Jurkat cells, using PPP2R1B antibody (CAB6703) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse lung using PPP2R1B Antibody (CAB6703) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of MCF7 cells using PPP2R1B antibody (CAB6703). |
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