Anti-PPIH Antibody (CAB12274)
- SKU:
- CAB12274
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-PPIH Antibody |
| 抗体コード: | CAB12274 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human PPIH (NP_006338.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | HepG2, Rat testis, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human PPIH (NP_006338.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAVA NSSP VNPV VFFD VSIG GQEV GRMK IELF ADVV PKTA ENFR QFCT GEFR KDGV PIGY KGST FHRV IKDF MIQG GDFV NGDG TGVA SIYR GPFA DENF KLRH SAPG LLSM ANSG PSTN GCQF FITC SKCD WLDG KHVV FGKI IDGL LVMR KIEN VPTG PNNK PKLP VVIS QCGE M |
| 遺伝子ID: | 10465 |
| Uniprot: | O43447 |
| セルラーロケーション: | Cytoplasm, Nucleus speckle |
| 計算された分子量: | 14kDa/19kDa |
| 観察された分子量: | 19kDa |
| 同義語: | PPIH, CYP-20, CYPH, SnuCyp-20, USA-CYP |
| バックグラウンド: | The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. |
| UniProt Protein Function: | PPIH: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex. May act as a chaperone. Belongs to the cyclophilin-type PPIase family. PPIase H subfamily. |
| UniProt Protein Details: | Protein type:Cyclophilin; EC 5.2.1.8; Isomerase; RNA processing; Spliceosome Chromosomal Location of Human Ortholog: 1p34.2 Cellular Component: cytoplasm; nuclear speck; nucleoplasm; spliceosome; U4/U6 x U5 tri-snRNP complex Molecular Function:cyclosporin A binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; ribonucleoprotein binding Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of viral genome replication; protein complex assembly |
| NCBI Summary: | The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43447 |
| NCBI GenInfo Identifier: | 37082225 |
| NCBI Gene ID: | 10465 |
| NCBI Accession: | O43447.1 |
| UniProt Secondary Accession: | O43447,A6NNE7, |
| UniProt Related Accession: | O43447 |
| Molecular Weight: | 19kDa |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase H |
| NCBI Synonym Full Names: | peptidylprolyl isomerase H |
| NCBI Official Symbol: | PPIH |
| NCBI Official Synonym Symbols: | CYPH; CYP-20; USA-CYP; SnuCyp-20 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase H |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase H |
| UniProt Synonym Protein Names: | Rotamase H; Small nuclear ribonucleoprotein particle-specific cyclophilin H; CypH; U-snRNP-associated cyclophilin SnuCyp-20; USA-CYP |
| UniProt Gene Name: | PPIH |
 | Western blot analysis of extracts of various cell lines, using PPIH antibody (CAB12274) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
View AllClose