| UniProt Protein Function: | Oct7: Transcription factor that binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a nonconserved spacer region of 0, 2, or 3 nucleotides. Positively regulates the genes under the control of corticotropin-releasing hormone (CRH) and CRH II promoters. Interacts with PQBP1. Expressed specifically in the neuroectodermal cell lineage. Belongs to the POU transcription factor family. Class- 3 subfamily. 3 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Transcription factor; Motility/polarity/chemotaxis; DNA-binding Chromosomal Location of Human Ortholog: 6q16 Cellular Component: transcription factor complex; nucleus Molecular Function:identical protein binding; protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: epidermis development; transcription, DNA-dependent; positive regulation of multicellular organism growth; hypothalamus cell differentiation; regulation of axonogenesis; astrocyte development; myelination in the peripheral nervous system; neuron differentiation; neurohypophysis development; positive regulation of cell proliferation; cerebral cortex radially oriented cell migration; positive regulation of transcription from RNA polymerase II promoter; forebrain ventricular zone progenitor cell division |
| NCBI Summary: | This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P20265 |
| NCBI GenInfo Identifier: | 51702521 |
| NCBI Gene ID: | 5454 |
| NCBI Accession: | NP_005595.2 |
| UniProt Secondary Accession: | P20265,Q14960, Q86V54, Q9UJL0, |
| UniProt Related Accession: | P20265 |
| Molecular Weight: | 26,841 Da |
| NCBI Full Name: | POU domain, class 3, transcription factor 2 |
| NCBI Synonym Full Names: | POU class 3 homeobox 2 |
| NCBI Official Symbol: | POU3F2 |
| NCBI Official Synonym Symbols: | BRN2; OCT7; OTF7; OTF-7; POUF3; brn-2; oct-7; N-Oct3 |
| NCBI Protein Information: | POU domain, class 3, transcription factor 2; brain-2; octamer-binding protein 7; octamer-binding transcription factor 7; brain-specific homeobox/POU domain protein 2; nervous system-specific octamer-binding transcription factor N-Oct-3 |
| UniProt Protein Name: | POU domain, class 3, transcription factor 2 |
| UniProt Synonym Protein Names: | Brain-specific homeobox/POU domain protein 2; Brain-2; Brn-2; Nervous system-specific octamer-binding transcription factor N-Oct-3; Octamer-binding protein 7; Oct-7; Octamer-binding transcription factor 7; OTF-7 |
| Protein Family: | POU domain, class 3, transcription factor |
| UniProt Gene Name: | POU3F2 |
| UniProt Entry Name: | PO3F2_HUMAN |
