Anti-POSTN Antibody (CAB14556)
- SKU:
- CAB14556
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-POSTN Antibody |
| 抗体コード: | CAB14556 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 472-751 of human POSTN (NP_001129408.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 472-751 of human POSTN (NP_001129408.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CMEK GSKQ GRNG AIHI FREI IKPA EKSL HEKL KQDK RFST FLSL LEAA DLKE LLTQ PGDW TLFV PTND AFKG MTSE EKEI LIRD KNAL QNII LYHL TPGV FIGK GFEP GVTN ILKT TQGS KIFL KEVN DTLL VNEL KSKE SDIM TTNG VIHV VDKL LYPA DTPV GNDQ LLEI LNKL IKYI QIKF VRGS TFKE IPVT VYKP IIKK YTKI IDGV PVEI TEKE TREE RIIT GPEI KYTR ISTG GGET EETL KKLL QEDT PVRK LQAN KKVQ GSRR RLRE GRSQ |
| 遺伝子ID: | 10631 |
| Uniprot: | Q15063 |
| セルラーロケーション: | Golgi apparatus, Secreted, extracellular matrix, extracellular space |
| 計算された分子量: | 80kDa/83kDa/87kDa/90kDa/93kDa |
| 観察された分子量: | 93kDa |
| 同義語: | POSTN, OSF-2, OSF2, PDLPOSTN, PN, periostin |
| バックグラウンド: | This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | POSTN: Binds to heparin. Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 13q13.3 Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; trans-Golgi network Molecular Function:heparin binding; protein binding; cell adhesion molecule binding Biological Process: tissue development; extracellular matrix organization and biogenesis; regulation of Notch signaling pathway; cell adhesion; skeletal development |
| NCBI Summary: | This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q15063 |
| NCBI GenInfo Identifier: | 93138709 |
| NCBI Gene ID: | 10631 |
| NCBI Accession: | Q15063.2 |
| UniProt Secondary Accession: | Q15063,Q15064, Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9, B1ALD8 C0IMJ1, C0IMJ2, C0IMJ4, D2KRH7, F5H628, |
| UniProt Related Accession: | Q15063 |
| Molecular Weight: | 80,357 Da |
| NCBI Full Name: | Periostin |
| NCBI Synonym Full Names: | periostin, osteoblast specific factor |
| NCBI Official Symbol: | POSTN |
| NCBI Official Synonym Symbols: | PN; OSF2; OSF-2; PDLPOSTN; periostin |
| NCBI Protein Information: | periostin; periodontal ligament-specific periostin; osteoblast specific factor 2 (fasciclin I-like) |
| UniProt Protein Name: | Periostin |
| UniProt Synonym Protein Names: | Osteoblast-specific factor 2; OSF-2 |
| Protein Family: | Periostin |
| UniProt Gene Name: | POSTN |
| UniProt Entry Name: | POSTN_HUMAN |
 | Western blot analysis of extracts of Rat lung, using POSTN antibody (CAB14556) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
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