Anti-PON2 Antibody (CAB19853)[KO Validated]

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SKU:
CAB19853
Product type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
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Description

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抗体名:Anti-PON2 Antibody [KO Validated]
抗体コード:CAB19853
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC IF
反応性:Human, Rat
宿主種:Rabbit
免疫原:Recombinant protein of human PON2.
申し込み:WB IHC IF
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
反応性:Human, Rat
ポジティブサンプル:HeLa
免疫原:Recombinant protein of human PON2.
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:5445
Uniprot:Q15165
セルラーロケーション:Membrane, Peripheral membrane protein
計算された分子量:37kDa/39kDa
観察された分子量:42KDa
Anti-PON2 Antibody [KO Validated] (CAB19853)Western blot analysis of extracts from normal (control) and PON2 knockout (KO) HeLa cells, using PON2 antibody (CAB19853) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
同義語:PON2
バックグラウンド:This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Protein Function:PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.1.81; Hydrolase; EC 3.1.1.2; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: mitochondrion; lysosome; plasma membrane; extracellular region; nucleus

Molecular Function:identical protein binding; arylesterase activity; metal ion binding

Biological Process: response to oxidative stress; aromatic compound catabolic process

UniProt Code:Q15165
NCBI GenInfo Identifier:325511384
NCBI Gene ID:
NCBI Accession:Q15165.3
Molecular Weight:
NCBI Full Name:Serum paraoxonase/arylesterase 2
UniProt Protein Name:Serum paraoxonase/arylesterase 2
UniProt Synonym Protein Names:Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2
Protein Family:Serum paraoxonase/arylesterase
UniProt Gene Name:PON2  
UniProt Entry Name:PON2_HUMAN
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