Anti-POLD3 Antibody (CAB7243)
- SKU:
- CAB7243
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-POLD3 Antibody |
抗体コード: | CAB7243 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 197-466 of human POLD3 (NP_006582.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
反応性: | Human, Mouse |
ポジティブサンプル: | THP-1, HepG2, HeLa, MCF7, H460, Mouse brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 197-466 of human POLD3 (NP_006582.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ASKA AAKT QETN KETK TEAK EVTN ASAA GNKA PGKG NMMS NFFG KAAM NKFK VNLD SEQA VKEE KIVE QPTV SVTE PKLA TPAG LKKS SKKA EPVK VLQK EKKR GKRV ALSD DETK ETEN MRKK RRRI KLPE SDSS EDEV FPDS PGAY EAES PSPP PPPS PPLE PVPK TEPE PPSV KSSS GENK RKRK RVLK SKTY LDGE GCIV TEKV YESE SCTD SEEE LNMK TSSV HRPP AMTV KKEP REER KGPK KGTA ALGK ANRQ VSIT GFFQ RK |
遺伝子ID: | 10714 |
Uniprot: | Q15054 |
セルラーロケーション: | Nucleus |
計算された分子量: | 39kDa/46kDa/51kDa |
観察された分子量: | 51kDa |
同義語: | POLD3, P66, P68, PPP1R128 |
バックグラウンド: | This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. |
UniProt Protein Function: | POLD3: Required for optimal DNA polymerase delta activity. |
UniProt Protein Details: | Protein type:Nucleotide Metabolism - pyrimidine; DNA replication; Nucleotide Metabolism - purine Chromosomal Location of Human Ortholog: 11q14 Cellular Component: mitochondrion; nucleoplasm; nucleus Molecular Function:DNA-directed DNA polymerase activity; protein binding Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA strand elongation during DNA replication; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; telomere maintenance; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair |
NCBI Summary: | This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012] |
UniProt Code: | Q15054 |
NCBI GenInfo Identifier: | 17375506 |
NCBI Gene ID: | 10714 |
NCBI Accession: | Q15054.2 |
UniProt Secondary Accession: | Q15054,Q32MZ9, Q32N00, B7ZAI6, |
UniProt Related Accession: | Q15054 |
Molecular Weight: | 39,320 Da |
NCBI Full Name: | DNA polymerase delta subunit 3 |
NCBI Synonym Full Names: | DNA polymerase delta 3, accessory subunit |
NCBI Official Symbol: | POLD3 |
NCBI Official Synonym Symbols: | P66; P68; PPP1R128 |
NCBI Protein Information: | DNA polymerase delta subunit 3 |
UniProt Protein Name: | DNA polymerase delta subunit 3 |
UniProt Synonym Protein Names: | DNA polymerase delta subunit p66 |
UniProt Gene Name: | POLD3 |
UniProt Entry Name: | DPOD3_HUMAN |
View AllClose