Anti-POLD2 Antibody (CAB6834)
- SKU:
- CAB6834
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-POLD2 Antibody |
抗体コード: | CAB6834 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-360 of human POLD2 (NP_006221.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, HL-60, HepG2, BT-474, NCI-H460, Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-360 of human POLD2 (NP_006221.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LQPE EKCC VVGT LFKA MPLQ PSIL REVS EEHN LLPQ PPRS KYIH PDDE LVLE DELQ RIKL KGTI DVSK LVTG TVLA VFGS VRDD GKFL VEDY CFAD LAPQ KPAP PLDT DRFV LLVS GLGL GGGG GESL LGTQ LLVD VVTG QLGD EGEQ CSAA HVSR VILA GNLL SHST QSRD SINK AKYL TKKT QAAS VEAV KMLD EILL QLSA SVPV DVMP GEFD PTNY TLPQ QPLH PCMF PLAT AYST L |
遺伝子ID: | 5425 |
Uniprot: | P49005 |
セルラーロケーション: | Nucleus |
計算された分子量: | 51kDa |
観察された分子量: | 51kDa |
同義語: | POLD2 |
バックグラウンド: | This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. |
UniProt Protein Function: | POLD2: The function of the small subunit is not yet clear. Belongs to the DNA polymerase delta/II small subunit family. |
UniProt Protein Details: | Protein type:DNA replication; EC 2.7.7.7; Nucleotide Metabolism - pyrimidine; DNA repair, damage; Nucleotide Metabolism - purine; Transferase Chromosomal Location of Human Ortholog: 7p13 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA-directed DNA polymerase activity; protein binding Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA replication; DNA strand elongation during DNA replication; mismatch repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; telomere maintenance; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair |
NCBI Summary: | This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA). Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Mar 2012] |
UniProt Code: | P49005 |
NCBI GenInfo Identifier: | 1352307 |
NCBI Gene ID: | 5425 |
NCBI Accession: | P49005.1 |
UniProt Secondary Accession: | P49005,A4D2J4, B2R5S4, |
UniProt Related Accession: | P49005 |
Molecular Weight: | 51,289 Da |
NCBI Full Name: | DNA polymerase delta subunit 2 |
NCBI Synonym Full Names: | DAN polymerase delta 2, accessory subunit |
NCBI Official Symbol: | POLD2 |
NCBI Protein Information: | DNA polymerase delta subunit 2 |
UniProt Protein Name: | DNA polymerase delta subunit 2 |
UniProt Synonym Protein Names: | DNA polymerase delta subunit p50 |
Protein Family: | DNA polymerase |
UniProt Gene Name: | POLD2 |
UniProt Entry Name: | DPOD2_HUMAN |
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