Anti-PNMA1 Antibody (CAB14558)
- SKU:
- CAB14558
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-PNMA1 Antibody |
| 抗体コード: | CAB14558 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human PNMA1 (NP_006020.4). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, 293T, HeLa, Mouse testis, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-353 of human PNMA1 (NP_006020.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAMT LLED WCRG MDVN SQRA LLVW GIPV NCDE AEIE ETLQ AAMP QVSY RMLG RMFW REEN AKAA LLEL TGAV DYAA IPRE MPGK GGVW KVLF KPPT SDAE FLER LHLF LARE GWTV QDVA RVLG FQNP TPTP GPEM PAEM LNYI LDNV IQPL VESI WYKR LTLF SGRD IPGP GEET FDPW LEHT NEVL EEWQ VSDV EKRR RLME SLRG PAAD VIRI LKSN NPAI TTAE CLKA LEQV FGSV ESSR DAQI KFLN TYQN PGEK LSAY VIRL EPLL QKVV EKGA IDKD NVNQ ARLE QVIA GANH SGAI RRQL WLTG AGEG PAPN LFQL LVQI REEE AKEE EEEA EATL LQLG LEGH F |
| 遺伝子ID: | 9240 |
| Uniprot: | Q8ND90 |
| セルラーロケーション: | Nucleus, nucleolus |
| 計算された分子量: | 39kDa |
| 観察された分子量: | 38kDa |
| 同義語: | PNMA1, MA1 |
| バックグラウンド: | This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. |
| UniProt Protein Function: | PNMA1: Belongs to the PNMA family |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: focal adhesion; cytoplasm; nucleolus Molecular Function:protein binding Biological Process: inflammatory response to antigenic stimulus; positive regulation of apoptosis |
| NCBI Summary: | The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders (Dalmau et al., 1999 [PubMed 10050892]). Some paraneoplastic syndromes affecting the nervous system are associated with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau et al., 1999 [PubMed 10050892]). Several of these antibodies are markers of specific neurologic syndromes associated with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal antibodies.[supplied by OMIM, May 2010] |
| UniProt Code: | Q8ND90 |
| NCBI GenInfo Identifier: | 52486265 |
| NCBI Gene ID: | 9240 |
| NCBI Accession: | NP_006020.4 |
| UniProt Secondary Accession: | Q8ND90,Q8C1C8, Q8VHZ4, |
| UniProt Related Accession: | Q8ND90 |
| Molecular Weight: | 39,761 Da |
| NCBI Full Name: | paraneoplastic antigen Ma1 |
| NCBI Synonym Full Names: | paraneoplastic Ma antigen 1 |
| NCBI Official Symbol: | PNMA1 |
| NCBI Official Synonym Symbols: | MA1 |
| NCBI Protein Information: | paraneoplastic antigen Ma1; 37 kDa neuronal protein; paraneoplastic neuronal antigen MA1; neuron- and testis-specific protein 1 |
| UniProt Protein Name: | Paraneoplastic antigen Ma1 |
| UniProt Synonym Protein Names: | 37 kDa neuronal protein; Neuron- and testis-specific protein 1 |
| UniProt Gene Name: | PNMA1 |
| UniProt Entry Name: | PNMA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PNMA1 antibody (CAB14558) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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