Anti-PNKP Antibody (CAB6693)
- SKU:
- CAB6693
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
抗体名: | Anti-PNKP Antibody |
抗体コード: | CAB6693 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human PNKP (NP_009185.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HL-60, HepG2, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human PNKP (NP_009185.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RTVA VKQL GVNP STTG TQEL KPGL EGSL GVGD TLYL VNGL HPLT LRWE ETRT PESQ PDTP PGTP LVSQ DEKR DAEL PKKR MRKS NPGW ENLE KLLV FTAA GVKP QGKV AGFD LDGT LITT RSGK VFPT GPSD WRIL YPEI PRKL RELE AEGY KLVI FTNQ MSIG RGKL PAEE FKAK VEAV VEKL GVPF QVLV ATHA GLYR KPVT GMWD HLQE QAND GTPI SIGD SIFV GDAA GRPA NWAP GRKK KDFS CADR LFAL NLGL P |
遺伝子ID: | 11284 |
Uniprot: | Q96T60 |
セルラーロケーション: | Nucleus |
計算された分子量: | 53kDa/57kDa |
観察された分子量: | 57kDa |
同義語: | PNKP, AOA4, EIEE10, MCSZ, PNK |
バックグラウンド: | This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay. |
UniProt Protein Function: | Pnk1: polynucleotide kinase 3'-phosphatase. May be involved in double-strand break repair by non-homologous end joining. Required for normal response to DNA damage by gamma-radiation or camptothecin in S. pombe. |
UniProt Protein Details: | Protein type:EC 3.1.3.32; EC 2.7.1.78; Phosphatase (non-protein); DNA-binding; Kinase, other Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: nucleoplasm; membrane; nucleolus; nucleus Molecular Function:protein binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; purine nucleotide binding; polynucleotide 3'-phosphatase activity; endonuclease activity; double-stranded DNA binding; damaged DNA binding; nucleotide kinase activity; ATP binding Biological Process: response to radiation; dephosphorylation; nucleotide-excision repair, DNA damage removal; DNA damage response, detection of DNA damage; response to oxidative stress; DNA-dependent DNA replication; DNA repair; nucleotide phosphorylation Disease: Microcephaly, Seizures, And Developmental Delay; Ataxia-oculomotor Apraxia 4 |
NCBI Summary: | This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010] |
UniProt Code: | Q96T60 |
NCBI GenInfo Identifier: | 50401132 |
NCBI Gene ID: | 11284 |
NCBI Accession: | Q96T60.1 |
UniProt Secondary Accession: | Q96T60,Q9BUL2, Q9P1V2, Q9UKU8, Q9UNF8, Q9UNI0, |
UniProt Related Accession: | Q96T60 |
Molecular Weight: | 521 |
NCBI Full Name: | Bifunctional polynucleotide phosphatase/kinase |
NCBI Synonym Full Names: | polynucleotide kinase 3'-phosphatase |
NCBI Official Symbol: | PNKP |
NCBI Official Synonym Symbols: | PNK; MCSZ; EIEE10 |
NCBI Protein Information: | bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP) |
UniProt Protein Name: | Bifunctional polynucleotide phosphatase/kinase |
UniProt Synonym Protein Names: | DNA 5'-kinase/3'-phosphatase; Polynucleotide kinase-3'-phosphataseIncluding the following 2 domains:Polynucleotide 3'-phosphatase (EC:3.1.3.32)Alternative name(s):2'(3')-polynucleotidase |
UniProt Gene Name: | PNKP |
UniProt Entry Name: | PNKP_HUMAN |