Anti-PLXNB2 Antibody (CAB10069)
- SKU:
- CAB10069
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PLXNB2 Antibody |
| 抗体コード: | CAB10069 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, SH-SY5Y, SKOV3, HepG2, 22Rv1, Mouse brain, Mouse liver, Mouse kidney, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ALLR TEAG AFEY VPDP TFEN FTGG VKKQ VNKL IHAR GTNL NKAM TLQE AEAF VGAE RCTM KTLT ETDL YCEP PEVQ PPPK RRQK RDTT HNLP EFIV KFGS REWV LGRV EYDT RVSD VPLS L |
| 遺伝子ID: | 23654 |
| Uniprot: | O15031 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 205kDa |
| 観察された分子量: | 80kDa |
| 同義語: | PLXNB2, MM1, Nbla00445, PLEXB2, dJ402G11.3, plexin-B2 |
| バックグラウンド: |
| UniProt Protein Function: | PLXNB2: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). Belongs to the plexin family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: cell surface; integral to plasma membrane; intracellular Molecular Function:protein binding; semaphorin receptor activity Biological Process: regulation of cell shape; regulation of protein amino acid phosphorylation; neuroblast proliferation; neural tube closure; positive regulation of axonogenesis; brain development |
| NCBI Summary: | Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O15031 |
| NCBI GenInfo Identifier: | 118341393 |
| NCBI Gene ID: | 23654 |
| NCBI Accession: | AAI27771.1 |
| UniProt Secondary Accession: | O15031,Q7KZU3, Q9BSU7, A6QRH0, |
| UniProt Related Accession: | O15031 |
| Molecular Weight: | 205,127 Da |
| NCBI Full Name: | PLXNB2 protein |
| NCBI Synonym Full Names: | plexin B2 |
| NCBI Official Symbol: | PLXNB2 |
| NCBI Official Synonym Symbols: | MM1; PLEXB2; Nbla00445; dJ402G11.3 |
| NCBI Protein Information: | plexin-B2 |
| UniProt Protein Name: | Plexin-B2 |
| UniProt Synonym Protein Names: | MM1 |
| Protein Family: | Plexin |
| UniProt Gene Name: | PLXNB2 |
| UniProt Entry Name: | PLXB2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PLXNB2 antibody (CAB10069) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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