Anti-PLK2 Antibody (CAB7066)
- SKU:
- CAB7066
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PLK2 Antibody |
| 抗体コード: | CAB7066 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 322-671 of human PLK2 (NP_001239155.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | MCF7 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 322-671 of human PLK2 (NP_001239155.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QGFT PDRL SSSC CHTV PDFH LSSP AKNF FKKA AAAL FGGK KDKA RYID THNR VSKE DEDI YKLR HDLK KTSI TQQP SKHR TDEE LQPP TTTV ARSG TPAV ENKQ QIGD AIRM IVRG TLGS CSSS SECL EDST MGSV ADTV ARVL RGCL ENMP EADC IPKE QLST SFQW VTKW VDYS NKYG FGYQ LSDH TVGV LFNN GAHM SLLP DKKT VHYY AELG QCSV FPAT DAPE QFIS QVTV LKYF SHYM EENL MDGG DLPS VTDI RRPR LYLL QWLK SDKA LMML FNDG TFQV NFYH DHTK IIIC SQNE EYLL TYIN EDRI STTF RLTT LLMS GCSS ELKN RMEY ALNM LLQR CN |
| 遺伝子ID: | 10769 |
| Uniprot: | Q9NYY3 |
| セルラーロケーション: | Cell projection, Cytoplasm, centriole, centrosome, cytoskeleton, dendrite, microtubule organizing center |
| 計算された分子量: | 78kDa |
| 観察された分子量: | 68kDa |
| 同義語: | PLK2, SNK, hPlk2, hSNK |
| バックグラウンド: | The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | PLK2: a kinase of the PLK family. Participates in a mitotic checkpoint in which p53-dependent activation Plk2 prevents mitotic catastrophe following spindle damage. Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. Apparently plays a role for Plk2 in the cell cycle. |
| UniProt Protein Details: | Protein type:EC 2.7.11.21; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Tumor suppressor; Other group; PLK family Chromosomal Location of Human Ortholog: 5q12.1-q13.2 Cellular Component: centriole; centrosome; dendrite; intracellular Molecular Function:protein serine/threonine kinase activity; signal transducer activity; protein binding; protein complex binding; ATP binding Biological Process: regulation of centriole replication; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; mitotic cell cycle checkpoint; regulation of synaptic plasticity; protein amino acid phosphorylation; memory; mitotic spindle organization and biogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; Ras protein signal transduction; Rap protein signal transduction; G1/S transition of mitotic cell cycle; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9NYY3 |
| NCBI GenInfo Identifier: | 22096374 |
| NCBI Gene ID: | 10769 |
| NCBI Accession: | Q9NYY3.3 |
| UniProt Secondary Accession: | Q9NYY3,O60679, Q96CV7, Q9UE61, |
| UniProt Related Accession: | Q9NYY3 |
| Molecular Weight: | 78,237 Da |
| NCBI Full Name: | Serine/threonine-protein kinase PLK2 |
| NCBI Synonym Full Names: | polo-like kinase 2 |
| NCBI Official Symbol: | PLK2 |
| NCBI Official Synonym Symbols: | SNK; hSNK; hPlk2 |
| NCBI Protein Information: | serine/threonine-protein kinase PLK2; PLK-2; serum-inducible kinase; serine/threonine-protein kinase SNK |
| UniProt Protein Name: | Serine/threonine-protein kinase PLK2 |
| UniProt Synonym Protein Names: | Polo-like kinase 2; PLK-2; hPlk2; Serine/threonine-protein kinase SNK; hSNK; Serum-inducible kinase |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | PLK2 |
| UniProt Entry Name: | PLK2_HUMAN |
 | Western blot analysis of extracts of MCF-7 cells, using PLK2 antibody (CAB7066) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 300s. |
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