Anti-PLB1 Antibody (CAB10429)
- SKU:
- CAB10429
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-PLB1 Antibody |
抗体コード: | CAB10429 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1110-1415 of human PLB1 (NP_694566.4). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-431, U-87MG, HL-60, HT-29, Mouse testis, Mouse lung, Mouse skeletal muscle, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1110-1415 of human PLB1 (NP_694566.4). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ARPN NSSD LPTS WRGL SWSI GGDG NLET HTTL PNIL KKFN PYLL GFST STWE GTAG LNVA AEGA RARD MPAQ AWDL VERM KNSP DINL EKDW KLVT LFIG VNDL CHYC ENPE AHLA TEYV QHIQ QALD ILSE ELPR AFVN VVEV MELA SLYQ GQGG KCAM LAAQ NNCT CLRH SQSS LEKQ ELKK VNWN LQHG ISSF SYWH QYTQ REDF AVVV QPFF QNTL TPLN ERGD TDLT FFSE DCFH FSDR GHAE MAIA LWNN MLEP VGRK TTSN NFTH SRAK LKCP SPES PYLY TLRN SRLL PDQA EEAP EV |
遺伝子ID: | 151056 |
Uniprot: | Q6P1J6 |
セルラーロケーション: | Apical cell membrane, Single-pass type I membrane protein |
計算された分子量: | 47kDa/54kDa/85kDa/161kDa/163kDa |
観察された分子量: | 170kDa |
同義語: | PLB1, PLB, PLB/LIP, hPLB |
バックグラウンド: | This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. |
UniProt Protein Function: | PLB1: Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.1.4; EC 3.1.1.5; Membrane protein, integral; Phospholipase Chromosomal Location of Human Ortholog: 2p23.2 Cellular Component: plasma membrane Molecular Function:phospholipase A2 activity; retinyl-palmitate esterase activity Biological Process: retinoid metabolic process |
NCBI Summary: | This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids. In addition, it displays lipase and retinyl ester hydrolase activities. The encoded protein is highly conserved and is composed of a large, glycosylated extracellular domain composed of four tandem homologous domains, followed by a hydrophobic segment that anchors the enzyme to the membrane and a short C-terminal cytoplasmic tail. This gene has been identified as a candidate rheumatoid arthritis risk gene. [provided by RefSeq, Jul 2016] |
UniProt Code: | Q6P1J6 |
NCBI GenInfo Identifier: | 296452994 |
NCBI Gene ID: | 151056 |
NCBI Accession: | Q6P1J6.3 |
UniProt Secondary Accession: | Q6P1J6,Q53S03, Q8IUP7, Q96DP9, A8KAX2, |
UniProt Related Accession: | Q6P1J6 |
Molecular Weight: | 163kDa |
NCBI Full Name: | Phospholipase B1, membrane-associated |
NCBI Synonym Full Names: | phospholipase B1 |
NCBI Official Symbol: | PLB1 |
NCBI Official Synonym Symbols: | PLB; PLB/LIP |
NCBI Protein Information: | phospholipase B1, membrane-associated |
UniProt Protein Name: | Phospholipase B1, membrane-associated |
UniProt Synonym Protein Names: | Phospholipase B/lipase; PLB/LIP |
Protein Family: | Phospholipase |
UniProt Gene Name: | PLB1 |
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