Anti-PKP2 Antibody (CAB5507)
- SKU:
- CAB5507
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PKP2 Antibody |
| 抗体コード: | CAB5507 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 578-837 of human PKP2 (NP_001005242.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Raji, Mouse kidney, Mouse liver, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 578-837 of human PKP2 (NP_001005242.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LPEK YSQN IYIQ NRNI QTDN NKSI GCFG SRSR KVKE QYQD VPMP EEKS NPKG VEWL WHSI VIRM YLSL IAKS VRNY TQEA SLGA LQNL TAGS GPMP TSVA QTVV QKES GLQH TRKM LHVG DPSV KKTA ISLL RNLS RNLS LQNE IAKE TLPD LVSI IPDT VPST DLLI ETTA SACY TLNN IIQN SYQN ARDL LNTG GIQK IMAI SAGD AYAS NKAS KAAS VLLY SLWA HTEL HHAY KKAQ FKKT DFVN SRTA KAYH SLKD |
| 遺伝子ID: | 5318 |
| Uniprot: | Q99959 |
| セルラーロケーション: | Cell junction, Nucleus, desmosome |
| 計算された分子量: | 92kDa/97kDa |
| 観察された分子量: | 95-105kDa |
| 同義語: | PKP2, ARVD9 |
| バックグラウンド: | This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. |
| UniProt Protein Function: | plakophilin 2: May play a role in junctional plaques. Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9); also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 12p11 Cellular Component: nucleoplasm; desmosome; adherens junction; plasma membrane; integral to membrane; intermediate filament; intercellular junction; nucleus; cell junction Molecular Function:protein binding; sodium channel regulator activity; protein kinase C binding; intermediate filament binding; protein complex scaffold Biological Process: negative regulation of cell proliferation; cell-cell adhesion; gap junction assembly; heart development; lipid homeostasis; ventricular cardiac muscle morphogenesis; intermediate filament bundle assembly; maintenance of organ identity; negative regulation of cell migration Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 9 |
| NCBI Summary: | This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99959 |
| NCBI GenInfo Identifier: | 296452867 |
| NCBI Gene ID: | 5318 |
| NCBI Accession: | Q99959.2 |
| UniProt Secondary Accession: | Q99959,Q4VC01, Q99960, A0AV37, B8QFA1, B8QGS6, B8QGS7 D3DUW9, |
| UniProt Related Accession: | Q99959 |
| Molecular Weight: | 92,756 Da |
| NCBI Full Name: | Plakophilin-2 |
| NCBI Synonym Full Names: | plakophilin 2 |
| NCBI Official Symbol: | PKP2 |
| NCBI Official Synonym Symbols: | ARVD9 |
| NCBI Protein Information: | plakophilin-2 |
| UniProt Protein Name: | Plakophilin-2 |
| Protein Family: | Plakophilin |
| UniProt Gene Name: | PKP2 |
| UniProt Entry Name: | PKP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PKP2 antibody (CAB5507) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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