Anti-PITX2 Antibody (CAB16417)
- SKU:
- CAB16417
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-PITX2 Antibody |
抗体コード: | CAB16417 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human PITX2 (NP_000316.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-324 of human PITX2 (NP_000316.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MNCM KGPL HLEH RAAG TKLS AVSS SSCH HPQP LAMA SVLA PGQP RSLD SSKH RLEV HTIS DTSS PEAA EKDK SQQG KNED VGAE DPSK KKRQ RRQR THFT SQQL QELE ATFQ RNRY PDMS TREE IAVW TNLT EARV RVWF KNRR AKWR KRER NQQA ELCK NGFG PQFN GLMQ PYDD MYPG YSYN NWAA KGLT SASL STKS FPFF NSMN VNPL SSQS MFSP PNSI SSMS MSSS MVPS AVTG VPGS SLNS LNNL NNLS SPSL NSAV PTPA CPYA PPTP PYVY RDTC NSSL ASLR LKAK QHSS FGYA SVQN PASN LSAC QYAV DRPV |
遺伝子ID: | 5308 |
Uniprot: | Q99697 |
セルラーロケーション: | Nucleus |
計算された分子量: | 30kDa/35kDa |
観察された分子量: | Refer to figures |
同義語: | PITX2, ARP1, ASGD4, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS |
バックグラウンド: | This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. |
UniProt Protein Function: | Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo. |
NCBI Summary: | This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99697 |
NCBI GenInfo Identifier: | 6174907 |
NCBI Gene ID: | 5308 |
NCBI Accession: | Q99697.2 |
UniProt Secondary Accession: | Q99697,O60578, O60579, O60580, Q3KQX9, Q9BY17, A8K6C6 B2RA02, B3KXS0, |
UniProt Related Accession: | Q99697 |
Molecular Weight: | 30,336 Da |
NCBI Full Name: | Pituitary homeobox 2 |
NCBI Synonym Full Names: | paired like homeodomain 2 |
NCBI Official Symbol: | PITX2 |
NCBI Official Synonym Symbols: | RS; RGS; ARP1; Brx1; IDG2; IGDS; IHG2; PTX2; RIEG; IGDS2; IRID2; Otlx2; RIEG1 |
NCBI Protein Information: | pituitary homeobox 2 |
UniProt Protein Name: | Pituitary homeobox 2 |
UniProt Synonym Protein Names: | ALL1-responsive protein ARP1; Homeobox protein PITX2; Paired-like homeodomain transcription factor 2; RIEG bicoid-related homeobox transcription factor; Solurshin |
Protein Family: | Pituitary homeobox |
UniProt Gene Name: | PITX2 |
UniProt Entry Name: | PITX2_HUMAN |
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