Anti-PITPNM1 Antibody (CAB13063)
- SKU:
- CAB13063
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PITPNM1 Antibody |
| 抗体コード: | CAB13063 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-190 of human PITPNM1 (NP_004901.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | LO2, Mouse brain, Mouse eye, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-190 of human PITPNM1 (NP_004901.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EIET YYLP DGGQ QPNV FNLS GAER RQRI LDTI DIVR DAVA PGEY KAEE DPRL YHSV KTGR GPLS DDWA RTAA QTGP LMCA Y |
| 遺伝子ID: | 9600 |
| Uniprot: | O00562 |
| セルラーロケーション: | Cleavage furrow, Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus, Golgi stack membrane, Lipid droplet, Midbody, Peripheral membrane protein |
| 計算された分子量: | 134kDa |
| 観察された分子量: | 135kDa |
| 同義語: | PITPNM1, DRES9, NIR2, PITPNM, RDGB, RDGB1, RDGBA, RDGBA1, Rd9 |
| バックグラウンド: |
| UniProt Protein Function: | PITPNM1: putatively transfers phosphatidylinositol and phosphatidylcholine between membranes. Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Has higher affinity for the inactive, GDP-bound form of RHOA. Necessary for normal completion of cytokinesis and for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golgi. Binds calcium ions. Interacts with PIK4CA and with Pyk2 via its C-terminus. Phosphorylated on multiple sites by CDC2 at the onset of mitosis. CDC2-phosphorylated forms may interact with PLK1. Interacts with VAPB. Phosphorylated on threonine residues upon treatment with oleic acid. |
| UniProt Protein Details: | Protein type:Cell surface Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cytoplasm; membrane Molecular Function:phosphatidylinositol transporter activity; protein binding Biological Process: brain development; phototransduction |
| NCBI Summary: | PITPNM1 belongs to a family of membrane-associated phosphatidylinositol transfer domain-containing proteins that share homology with the Drosophila retinal degeneration B (rdgB) protein (Ocaka et al., 2005 [PubMed 15627748]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O00562 |
| NCBI GenInfo Identifier: | 118595707 |
| NCBI Gene ID: | 9600 |
| NCBI Accession: | O00562.4 |
| UniProt Secondary Accession: | O00562,Q6T7X3, Q8TBN3, Q9BZ73, A6NME4, |
| UniProt Related Accession: | O00562 |
| Molecular Weight: | 134,777 Da |
| NCBI Full Name: | Membrane-associated phosphatidylinositol transfer protein 1 |
| NCBI Synonym Full Names: | phosphatidylinositol transfer protein membrane associated 1 |
| NCBI Official Symbol: | PITPNM1 |
| NCBI Official Synonym Symbols: | Rd9; NIR2; RDGB; DRES9; RDGB1; RDGBA; PITPNM; RDGBA1 |
| NCBI Protein Information: | membrane-associated phosphatidylinositol transfer protein 1 |
| UniProt Protein Name: | Membrane-associated phosphatidylinositol transfer protein 1 |
| UniProt Synonym Protein Names: | Drosophila retinal degeneration B homolog; Phosphatidylinositol transfer protein, membrane-associated 1; PITPnm 1; Pyk2 N-terminal domain-interacting receptor 2; NIR-2 |
| Protein Family: | Membrane-associated phosphatidylinositol transfer protein |
| UniProt Gene Name: | PITPNM1 |
| UniProt Entry Name: | PITM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PITPNM1 Antibody (CAB13063) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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