Anti-PILRA Antibody (CAB17292)
- SKU:
- CAB17292
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-PILRA Antibody |
| 抗体コード: | CAB17292 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human PILRA. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse liver, Rat liver |
| 免疫原: | Recombinant protein of human PILRA. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 29992 |
| Uniprot: | Q9UKJ1 |
| セルラーロケーション: | |
| 計算された分子量: | 34kDa |
| 観察された分子量: | 45kDa |
| 同義語: | PILRA, FDF03 |
| バックグラウンド: | Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. |
| UniProt Protein Function: | PILRA: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: plasma membrane; integral to membrane Molecular Function:protein binding Biological Process: viral reproduction; signal transduction |
| NCBI Summary: | Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UKJ1 |
| NCBI GenInfo Identifier: | 30179909 |
| NCBI Gene ID: | 29992 |
| NCBI Accession: | NP_038467.2 |
| UniProt Secondary Accession: | Q9UKJ1,Q8NHI1, |
| UniProt Related Accession: | Q9UKJ1 |
| Molecular Weight: | 34,005 Da |
| NCBI Full Name: | paired immunoglobulin-like type 2 receptor alpha isoform 1 |
| NCBI Synonym Full Names: | paired immunoglobin-like type 2 receptor alpha |
| NCBI Official Symbol: | PILRA |
| NCBI Official Synonym Symbols: | FDF03 |
| NCBI Protein Information: | paired immunoglobulin-like type 2 receptor alpha; cell surface receptor FDF03; inhibitory receptor PILR-alpha |
| UniProt Protein Name: | Paired immunoglobulin-like type 2 receptor alpha |
| UniProt Synonym Protein Names: | Cell surface receptor FDF03; Inhibitory receptor PILR-alpha |
| Protein Family: | Paired immunoglobulin-like type 2 receptor |
| UniProt Gene Name: | PILRA |
| UniProt Entry Name: | PILRA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PILRA Rabbit pAb (CAB17292) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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