Anti-PIK3R5 Antibody (CAB16266)
- SKU:
- CAB16266
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PIK3R5 Antibody |
| 抗体コード: | CAB16266 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic Peptide of human PIK3R5 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic Peptide of human PIK3R5 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 23533 |
| Uniprot: | Q8WYR1 |
| セルラーロケーション: | Cytoplasm, Membrane, Nucleus, Peripheral membrane protein |
| 計算された分子量: | 54kDa/97kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | PIK3R5, F730038I15Rik, FOAP-2, P101-PI3K, p101 |
| バックグラウンド: | Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. |
| UniProt Protein Function: | PIK3R5: Regulatory subunit of the PI3K gamma complex. Heterodimer of a catalytic subunit (PIK3CG/p120) and a regulatory (PIK3R5a/p101) subunit. Interacts with G beta gamma proteins. Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli. Greatly activated by G gamma proteins. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: membrane; cytoplasm; cytosol; nucleus Molecular Function:G-protein beta/gamma-subunit binding; 1-phosphatidylinositol-3-kinase regulator activity Biological Process: positive regulation of MAP kinase activity; G-protein coupled receptor protein signaling pathway; platelet activation; positive regulation of protein kinase B signaling cascade; phosphoinositide 3-kinase cascade; phospholipid metabolic process; phosphatidylinositol biosynthetic process; blood coagulation; regulation of phosphoinositide 3-kinase activity Disease: Ataxia-oculomotor Apraxia 3 |
| NCBI Summary: | Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q8WYR1 |
| NCBI GenInfo Identifier: | 74716480 |
| NCBI Gene ID: | 23533 |
| NCBI Accession: | Q8WYR1.1 |
| UniProt Secondary Accession: | Q8WYR1,Q5G936, Q5G938, Q5G939, Q8IZ23, Q9Y2Y2, B0LPH4 D3DTS3, |
| UniProt Related Accession: | Q8WYR1 |
| Molecular Weight: | 880 |
| NCBI Full Name: | Phosphoinositide 3-kinase regulatory subunit 5 |
| NCBI Synonym Full Names: | phosphoinositide-3-kinase, regulatory subunit 5 |
| NCBI Official Symbol: | PIK3R5 |
| NCBI Official Synonym Symbols: | p101; FOAP-2; P101-PI3K; F730038I15Rik |
| NCBI Protein Information: | phosphoinositide 3-kinase regulatory subunit 5; protein FOAP-2; ptdIns-3-kinase p101; PI3-kinase p101 subunit; phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit |
| UniProt Protein Name: | Phosphoinositide 3-kinase regulatory subunit 5 |
| UniProt Synonym Protein Names: | PI3-kinase p101 subunit; Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit; PtdIns-3-kinase regulatory subunit; Protein FOAP-2; PtdIns-3-kinase p101; p101-PI3K |
| Protein Family: | Phosphoinositide 3-kinase regulatory |
| UniProt Gene Name: | PIK3R5 |
| UniProt Entry Name: | PI3R5_HUMAN |
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