| UniProt Protein Function: | PIK3C3: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes. Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive. Part of a complex composed of PIK3R4 and PIK3CB. Interacts with RAB7A in the presence of PIK3R4. Ubiquitously expressed, with a highest expression in skeletal muscle. Belongs to the PI3/PI4-kinase family. |
| UniProt Protein Details: | Protein type:EC 2.7.1.137; Autophagy; Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; Kinase, lipid Chromosomal Location of Human Ortholog: 18q12.3 Cellular Component: membrane; late endosome; phagocytic vesicle; midbody; axoneme; phosphoinositide 3-kinase complex; cytosol Molecular Function:protein binding; 1-phosphatidylinositol-3-kinase activity; ATP binding; protein kinase activity Biological Process: phosphoinositide-mediated signaling; endosome organization and biogenesis; cytokinesis; protein amino acid phosphorylation; regulation of protein secretion; response to leucine; phosphoinositide phosphorylation; early endosome to late endosome transport; phospholipid metabolic process; phosphatidylinositol biosynthetic process; toll-like receptor signaling pathway; insulin receptor signaling pathway; innate immune response; protein processing; toll-like receptor 9 signaling pathway; autophagic vacuole formation |
| UniProt Code: | Q8NEB9 |
| NCBI GenInfo Identifier: | 74730233 |
| NCBI Gene ID: | 5289 |
| NCBI Accession: | Q8NEB9.1 |
| UniProt Secondary Accession: | Q8NEB9,Q15134, |
| UniProt Related Accession: | Q8NEB9 |
| Molecular Weight: | 101,549 Da |
| NCBI Full Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
| NCBI Synonym Full Names: | phosphatidylinositol 3-kinase, catalytic subunit type 3 |
| NCBI Official Symbol: | PIK3C3 |
| NCBI Official Synonym Symbols: | VPS34; Vps34; hVps34 |
| NCBI Protein Information: | phosphatidylinositol 3-kinase catalytic subunit type 3 |
| UniProt Protein Name: | Phosphatidylinositol 3-kinase catalytic subunit type 3 |
| UniProt Synonym Protein Names: | Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; hVps34 |
| UniProt Gene Name: | PIK3C3 |
| UniProt Entry Name: | PK3C3_HUMAN |
