Anti-PIGR Antibody (CAB14766)
- SKU:
- CAB14766
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PIGR Antibody |
| 抗体コード: | CAB14766 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 661-764 of human PIGR (NP_002635.2). |
| 申し込み: | IHC IF |
| 推奨希釈: | IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 661-764 of human PIGR (NP_002635.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ARAR HRKN VDRV SIRS YRTD ISMS DFEN SREF GAND NMGA SSIT QETS LGGK EEFV ATTE STTE TKEP KKAK RSSK EEAE MAYK DFLL QSST VAAE AQDG PQEA |
| 遺伝子ID: | 5284 |
| Uniprot: | P01833 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein |
| 計算された分子量: | 83kDa |
| 観察された分子量: |
| 同義語: | PIGR |
| バックグラウンド: | This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene. |
| UniProt Protein Function: | PIGR: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. |
| UniProt Protein Details: | Protein type:Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q31-q41 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; receptor complex Molecular Function:polymeric immunoglobulin receptor activity Biological Process: epidermal growth factor receptor signaling pathway; retinal homeostasis; detection of chemical stimulus involved in sensory perception of bitter taste; receptor clustering; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor Disease: Iga Nephropathy, Susceptibility To, 1 |
| NCBI Summary: | This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009] |
| UniProt Code: | P01833 |
| NCBI GenInfo Identifier: | 150421625 |
| NCBI Gene ID: | 5284 |
| NCBI Accession: | P01833.4 |
| UniProt Secondary Accession: | P01833,Q68D81, Q8IZY7, |
| UniProt Related Accession: | P01833 |
| Molecular Weight: | 764 |
| NCBI Full Name: | Polymeric immunoglobulin receptor |
| NCBI Synonym Full Names: | polymeric immunoglobulin receptor |
| NCBI Official Symbol: | PIGR |
| NCBI Protein Information: | polymeric immunoglobulin receptor; poly-Ig receptor; hepatocellular carcinoma associated protein TB6; hepatocellular carcinoma-associated protein TB6 |
| UniProt Protein Name: | Polymeric immunoglobulin receptor |
| UniProt Synonym Protein Names: | Hepatocellular carcinoma-associated protein TB6Secretory component |
| Protein Family: | Polymeric immunoglobulin receptor |
| UniProt Gene Name: | PIGR |
| UniProt Entry Name: | PIGR_HUMAN |
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