Anti-PI4KA Antibody (CAB19329)

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SKU:
CAB19329
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
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Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-PI4KA Antibody
抗体コード:CAB19329
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant protein of human PI4KA.
申し込み:WB IF
推奨希釈:WB 1:500 - 1:2000 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:HeLa, NIH/3T3, Mouse brain, Rat brain
免疫原:Recombinant protein of human PI4KA.
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:5297
Uniprot:P42356
セルラーロケーション:
計算された分子量:237kDa
観察された分子量:237kDa
Anti-PI4KA Antibody (CAB19329)Western blot - PI4KA Rabbit pAb (CAB19329)
同義語:PIK4CA, PMGYCHA, pi4K230, PI4K-ALPHA, PI4KA
バックグラウンド:This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4, 5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniProt Protein Function:PIK4CA: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Kinase, lipid; EC 2.7.1.67; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: focal adhesion; membrane; plasma membrane; cytosol

Molecular Function:1-phosphatidylinositol 4-kinase activity; protein binding; ATP binding

Biological Process: phosphoinositide-mediated signaling; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; signal transduction

Disease: Polymicrogyria, Perisylvian, With Cerebellar Hypoplasia And Arthrogryposis

NCBI Summary:This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014]
UniProt Code:P42356
NCBI GenInfo Identifier:218512114
NCBI Gene ID:5297
NCBI Accession:P42356.3
UniProt Secondary Accession:P42356,Q7Z625, Q9UPG2,
UniProt Related Accession:P42356
Molecular Weight:96,984 Da
NCBI Full Name:Phosphatidylinositol 4-kinase alpha
NCBI Synonym Full Names:phosphatidylinositol 4-kinase, catalytic, alpha
NCBI Official Symbol:PI4KA  
NCBI Official Synonym Symbols:PIK4CA; pi4K230; PI4K-ALPHA  
NCBI Protein Information:phosphatidylinositol 4-kinase alpha
UniProt Protein Name:Phosphatidylinositol 4-kinase alpha
Protein Family:Phosphatidylinositol 4-kinase
UniProt Gene Name:PI4KA  
UniProt Entry Name:PI4KA_HUMAN
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