Anti-PI4KA Antibody (CAB19329)
- SKU:
- CAB19329
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-PI4KA Antibody |
| 抗体コード: | CAB19329 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human PI4KA. |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, NIH/3T3, Mouse brain, Rat brain |
| 免疫原: | Recombinant protein of human PI4KA. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 5297 |
| Uniprot: | P42356 |
| セルラーロケーション: | |
| 計算された分子量: | 237kDa |
| 観察された分子量: | 237kDa |
 | Western blot - PI4KA Rabbit pAb (CAB19329) |
| 同義語: | PIK4CA, PMGYCHA, pi4K230, PI4K-ALPHA, PI4KA |
| バックグラウンド: | This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4, 5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| UniProt Protein Function: | PIK4CA: Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate. Expressed ubiquitously. Highest levels in placenta and brain. Little or no expression in lung, liver, pancreas, testis or leukocytes. This is a type II PtdIns-4-kinase activated by detergents such as triton and inhibited by adenosine. Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Kinase, lipid; EC 2.7.1.67; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: focal adhesion; membrane; plasma membrane; cytosol Molecular Function:1-phosphatidylinositol 4-kinase activity; protein binding; ATP binding Biological Process: phosphoinositide-mediated signaling; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; signal transduction Disease: Polymicrogyria, Perisylvian, With Cerebellar Hypoplasia And Arthrogryposis |
| NCBI Summary: | This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. [provided by RefSeq, Sep 2014] |
| UniProt Code: | P42356 |
| NCBI GenInfo Identifier: | 218512114 |
| NCBI Gene ID: | 5297 |
| NCBI Accession: | P42356.3 |
| UniProt Secondary Accession: | P42356,Q7Z625, Q9UPG2, |
| UniProt Related Accession: | P42356 |
| Molecular Weight: | 96,984 Da |
| NCBI Full Name: | Phosphatidylinositol 4-kinase alpha |
| NCBI Synonym Full Names: | phosphatidylinositol 4-kinase, catalytic, alpha |
| NCBI Official Symbol: | PI4KA |
| NCBI Official Synonym Symbols: | PIK4CA; pi4K230; PI4K-ALPHA |
| NCBI Protein Information: | phosphatidylinositol 4-kinase alpha |
| UniProt Protein Name: | Phosphatidylinositol 4-kinase alpha |
| Protein Family: | Phosphatidylinositol 4-kinase |
| UniProt Gene Name: | PI4KA |
| UniProt Entry Name: | PI4KA_HUMAN |