Anti-PI4K2A Antibody (CAB16546)
- SKU:
- CAB16546
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-PI4K2A Antibody |
抗体コード: | CAB16546 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 131-479 of human PI4K2A (NP_060895.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 131-479 of human PI4K2A (NP_060895.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | YQGS SGSY FVKD PQGR IIAV FKPK NEEP YGHL NPKW TKWL QKLC CPCC FGRD CLVL NQGY LSEA GASL VDQK LELN IVPR TKVV YLAS ETFN YSAI DRVK SRGK RLAL EKVP KVGQ RFNR IGLP PKVG SFQL FVEG YKDA DYWL RRFE AEPL PENT NRQL LLQF ERLV VLDY IIRN TDRG NDNW LIKY DCPM DSSS SRDT DWVV VKEP VIKV AAID NGLA FPLK HPDS WRAY PFYW AWLP QAKV PFSQ EIKD LILP KISD PNFV KDLE EDLY ELFK KDPG FDRG QFHK QIAV MRGQ ILNL TQAL KDNK SPLH LVQM PPVI VETA RSHQ RSSS ESYT QSFQ SRKP FFSW W |
遺伝子ID: | 55361 |
Uniprot: | Q9BTU6 |
セルラーロケーション: | Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Golgi apparatus, Lipid-anchor, Membrane, Membrane raft, Mitochondrion, dendrite, presynaptic cell membrane, synapse, synaptosome, trans-Golgi network membrane |
計算された分子量: | 54kDa |
観察された分子量: | 54kDa |
同義語: | PI4K2A, PI4KII, PIK42A |
バックグラウンド: | Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs. |
UniProt Protein Function: | PI4K2A: Together with PI4K2B and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells. Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. |
UniProt Protein Details: | Protein type:EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 10q24 Cellular Component: Golgi apparatus; neuron projection; mitochondrion; synaptic vesicle membrane; lysosomal membrane; integral to plasma membrane; dendrite; perikaryon; cytosol; lipid raft; presynaptic membrane; cell soma; membrane; early endosome membrane; intrinsic to membrane; cytoplasmic vesicle; cell junction; endosome Molecular Function:protein binding; 1-phosphatidylinositol 4-kinase activity; magnesium ion binding; ATP binding Biological Process: phosphoinositide phosphorylation; phospholipid metabolic process; basophil degranulation; phosphatidylinositol biosynthetic process |
NCBI Summary: | Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9BTU6 |
NCBI GenInfo Identifier: | 74752344 |
NCBI Gene ID: | 55361 |
NCBI Accession: | Q9BTU6.1 |
UniProt Secondary Accession: | Q9BTU6,Q9NSG8, D3DR59, |
UniProt Related Accession: | Q9BTU6 |
Molecular Weight: | 479 |
NCBI Full Name: | Phosphatidylinositol 4-kinase type 2-alpha |
NCBI Synonym Full Names: | phosphatidylinositol 4-kinase type 2 alpha |
NCBI Official Symbol: | PI4K2A |
NCBI Official Synonym Symbols: | PI4KII; PIK42A |
NCBI Protein Information: | phosphatidylinositol 4-kinase type 2-alpha; phosphatidylinositol 4-kinase type II-alpha; phosphatidylinositol 4-kinase type II (PI4KII) |
UniProt Protein Name: | Phosphatidylinositol 4-kinase type 2-alpha |
UniProt Synonym Protein Names: | Phosphatidylinositol 4-kinase type II-alpha |
Protein Family: | Phosphatidylinositol 4-kinase |
UniProt Gene Name: | PI4K2A |
UniProt Entry Name: | P4K2A_HUMAN |
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