| UniProt Protein Function: | PIK3CB: catalytic subunit of phosphoinositide-3-kinase beta. Catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol (PI), phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2). Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration and cell survival. PTEN reverses this process, and the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. Expressed ubiquitously. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; EC 2.7.1.153; Kinase, lipid Chromosomal Location of Human Ortholog: 3q22.3 Cellular Component: cytosol; intercellular bridge; nucleolus; nucleus; phosphoinositide 3-kinase complex; plasma membrane Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; phosphoinositide 3-kinase activity; protein binding Biological Process: activation of MAPK activity; cell migration; chemotaxis; G-protein coupled receptor protein signaling pathway; leukocyte migration; phosphatidylinositol biosynthetic process; phosphoinositide 3-kinase cascade; phosphoinositide-mediated signaling; platelet activation; positive regulation of autophagy; regulation of cell-matrix adhesion; regulation of phosphoinositide 3-kinase cascade; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
| UniProt Code: | P42338 |
| NCBI GenInfo Identifier: | 1171955 |
| NCBI Gene ID: | 5291 |
| NCBI Accession: | P42338.1 |
| UniProt Secondary Accession: | P42338,Q24JU2, D3DNF0, |
| UniProt Related Accession: | P42338 |
| Molecular Weight: | 122,762 Da |
| NCBI Full Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| NCBI Synonym Full Names: | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| NCBI Official Symbol: | PIK3CB |
| NCBI Official Synonym Symbols: | PI3K; PIK3C1; P110BETA; PI3KBETA |
| NCBI Protein Information: | phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| UniProt Protein Name: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| UniProt Synonym Protein Names: | Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; PtdIns-3-kinase subunit p110-beta; p110beta |
| Protein Family: | Phosphatidylinositol 4,5-bisphosphate 3-kinase |
| UniProt Gene Name: | PIK3CB |
| UniProt Entry Name: | PK3CB_HUMAN |
