Anti-Phospho-YB-1/YBX1-S102 Antibody (CABP1249)
- SKU:
- CABP1249
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- YBX1
- Synonyms:
- BP-8
- Synonyms:
- CBF-A
- Synonyms:
- CSDA2
- Synonyms:
- CSDB
- Synonyms:
- DBPB
- Synonyms:
- EFI-A
- Synonyms:
- MDR-NF1
- Synonyms:
- NSEP-1
- Synonyms:
- NSEP1
- Synonyms:
- YB-1
- Synonyms:
- YB1
Description
| 抗体名: | Phospho-YB-1/YBX1-S102 Rabbit pAb |
| 抗体コード: | CABP1249 |
| サイズ: | 50uL, 100uL |
| 同義語: | YBX1, BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1 |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A phospho synthetic peptide corresponding to residues surrounding S102 of Human YBX1. |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HepG2 |
| 免疫原: | A phospho synthetic peptide corresponding to residues surrounding S102 of Human YBX1. |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 4904 |
| Uniprot: | P67809 |
| セルラーロケーション: | Cytoplasm, Cytoplasmic granule, Nucleus, Secreted |
| 計算された分子量: | 35kDa |
| 観察された分子量: | 49KDa |
| UniProt Protein Function: | YB-1: a nuclear protein that binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors CCAAT-containing Y-box of HLA class II genes. Component of cytoplasmic messenger ribonucleoprotein particles (mRNPs). Interacts with AKT1, SFRS9, THOC4, MSH2, XRCC5, WRN and NCL. Can bind to DNA as a homomeric form, (EFI-A)n or as a heteromeric form in association with EFI-B. Homodimer in the presence of ATP. Involved in cisplatin resistance. Seems to be a negative regulatory factor. May play a role in both transcriptional and translational regulation of spermatogenesis. Found at very low levels at day 10 and levels increase at day 15 and persist throughout adulthood. |
| UniProt Protein Details: | Protein type:Transcription factor; RNA-binding; RNA splicing; RNA processing Chromosomal Location of Human Ortholog: 1p34 Cellular Component: nucleoplasm; nuclear membrane; intracellular membrane-bound organelle; stress granule; cytoplasm; nucleus; ribonucleoprotein complex; U12-dependent spliceosome Molecular Function:protein binding; DNA binding; RNA binding; double-stranded DNA binding; transcription factor activity; single-stranded DNA binding Biological Process: transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; negative regulation of striated muscle cell differentiation; regulation of transcription, DNA-dependent; in utero embryonic development; positive regulation of cell division; RNA splicing; positive regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | P67809 |
| NCBI GenInfo Identifier: | 34098946 |
| NCBI Gene ID: | 4904 |
| NCBI Accession: | NP_004550.2 |
| UniProt Secondary Accession: | P67809,P16990, P16991, Q14972, Q15325, Q5FVF0, |
| UniProt Related Accession: | P67809 |
| Molecular Weight: | 35,924 Da |
| NCBI Full Name: | nuclease-sensitive element-binding protein 1 |
| NCBI Synonym Full Names: | Y box binding protein 1 |
| NCBI Official Symbol: | YBX1 |
| NCBI Official Synonym Symbols: | YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1 |
| NCBI Protein Information: | nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit |
| UniProt Protein Name: | Nuclease-sensitive element-binding protein 1 |
| UniProt Synonym Protein Names: | CCAAT-binding transcription factor I subunit A; CBF-A; DNA-binding protein B; DBPB; Enhancer factor I subunit A; EFI-A; Y-box transcription factor; Y-box-binding protein 1 |
| Protein Family: | Nuclease-sensitive element-binding protein |
| UniProt Gene Name: | YBX1 |
| UniProt Entry Name: | YBOX1_HUMAN |