Anti-Phospho-VANGL2-S14/S17 Antibody (CABP1204)
- SKU:
- CABP1204
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- VANGL2
- Synonyms:
- LPP1
- Synonyms:
- LTAP
- Synonyms:
- STB1
- Synonyms:
- STBM
- Synonyms:
- STBM1
Frequently bought together:
Description
| 抗体名: | Phospho-VANGL2-S14/S17 Rabbit mAb |
| 抗体コード: | CABP1204 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | VANGL2, LPP1, LTAP, STB1, STBM, STBM1 |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S14/S17 of human VANGL2 |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S14/S17 of human VANGL2 |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 57216 |
| Uniprot: | Q9ULK5 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 59kDa |
| 観察された分子量: | 60KDa |
| UniProt Protein Function: | VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1q22-q23 Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane Molecular Function:protein binding Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure; sensory cilium biogenesis Disease: Neural Tube Defects |
| NCBI Summary: | The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011] |
| UniProt Code: | Q9ULK5 |
| NCBI GenInfo Identifier: | 38258849 |
| NCBI Gene ID: | 57216 |
| NCBI Accession: | Q9ULK5.2 |
| UniProt Secondary Accession: | Q9ULK5,Q5T212, D3DVE9, |
| UniProt Related Accession: | Q9ULK5 |
| Molecular Weight: | 59,714 Da |
| NCBI Full Name: | Vang-like protein 2 |
| NCBI Synonym Full Names: | VANGL planar cell polarity protein 2 |
| NCBI Official Symbol: | VANGL2 |
| NCBI Official Synonym Symbols: | LPP1; LTAP; STB1; STBM; STBM1 |
| NCBI Protein Information: | vang-like protein 2 |
| UniProt Protein Name: | Vang-like protein 2 |
| UniProt Synonym Protein Names: | Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2 |
| Protein Family: | Vang-like protein |
| UniProt Gene Name: | VANGL2 |
| UniProt Entry Name: | VANG2_HUMAN |