Anti-Phospho-Stathmin-S25 Antibody (CABP0220)
- SKU:
- CABP0220
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-Phospho-Stathmin-S25 Antibody |
| 抗体コード: | CABP0220 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S25 of human STMN1 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S25 of human STMN1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3925 |
| Uniprot: | P16949 |
| セルラーロケーション: | Cytoplasm, cytoskeleton |
| 計算された分子量: | 17kDa/19kDa |
| 観察された分子量: | 17kDa |
 | Western blot analysis of extracts of Jurkat cells, using Phospho-STMN1-S25 pAb (CABP0220) at 1:2000 dilution or STMN1 antibody (CAB14018).Jurkat cells were treated by PMA/TPA (200nM) for 10 minutes. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human breast carcinoma using Phospho-STMN1-S25 antibody (CABP0220). |
| 同義語: | STMN1, C1orf215, LAP18, Lag, OP18, PP17, PP19, PR22, SMN, stathmin |
| バックグラウンド: | This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | STMN1: a microtubule-associated protein involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Phosphorylation reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, nonleukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: cytoplasm; cytosol; intracellular; membrane; microtubule; neuron projection Molecular Function:protein binding; signal transducer activity; tubulin binding Biological Process: axonogenesis; brain development; microtubule depolymerization; mitotic spindle organization and biogenesis; negative regulation of microtubule polymerization; neurite development; positive regulation of cell motility; regulation of cytoskeleton organization and biogenesis; response to virus; signal transduction |
| NCBI Summary: | This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
| UniProt Code: | P16949 |
| NCBI GenInfo Identifier: | 134973 |
| NCBI Gene ID: | 3925 |
| NCBI Accession: | P16949.3 |
| UniProt Secondary Accession: | P16949,A2A2D1, B2R4E7, B7Z8N4, D3DPJ5, |
| UniProt Related Accession: | P16949 |
| Molecular Weight: | 19,824 Da |
| NCBI Full Name: | Stathmin |
| NCBI Synonym Full Names: | stathmin 1 |
| NCBI Official Symbol: | STMN1 |
| NCBI Official Synonym Symbols: | Lag; SMN; OP18; PP17; PP19; PR22; LAP18; C1orf215 |
| NCBI Protein Information: | stathmin |
| UniProt Protein Name: | Stathmin |
| UniProt Synonym Protein Names: | Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17 |
| Protein Family: | Stathmin |
| UniProt Gene Name: | STMN1 |
| UniProt Entry Name: | STMN1_HUMAN |