UniProt Protein Function: | STAT6: transcription factor of the STAT family. Plays a central role in IL4-mediated biological responses. Induces the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. May function in the differentiation of T helper 2 cells and class switch of immunoglobulins. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 12q13 Cellular Component: cytoplasm; cytosol; lipid raft; nuclear chromatin; nucleoplasm Molecular Function:identical protein binding; protein binding; protein phosphatase binding; signal transducer activity; transcription factor activity Biological Process: mammary gland epithelial cell proliferation; negative regulation of T-helper 2 type immune response; negative regulation of transcription from RNA polymerase II promoter; positive regulation of interferon type I production; positive regulation of isotype switching to IgE isotypes; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; signal transduction; T-helper 1 cell lineage commitment; transcription, DNA-dependent |
NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
UniProt Code: | P42226 |
NCBI GenInfo Identifier: | 1174459 |
NCBI Gene ID: | 6778 |
NCBI Accession: | P42226.1 |
UniProt Secondary Accession: | P42226,Q5FBW5, Q71UP4, A8K316, B7ZA27, F5GXI9, |
UniProt Related Accession: | P42226 |
Molecular Weight: | |
NCBI Full Name: | Signal transducer and activator of transcription 6 |
NCBI Synonym Full Names: | signal transducer and activator of transcription 6 |
NCBI Official Symbol: | STAT6 |
NCBI Official Synonym Symbols: | STAT6B; STAT6C; D12S1644; IL-4-STAT |
NCBI Protein Information: | signal transducer and activator of transcription 6 |
UniProt Protein Name: | Signal transducer and activator of transcription 6 |
UniProt Synonym Protein Names: | IL-4 Stat |
Protein Family: | Signal transducer and transcription activator |
UniProt Gene Name: | STAT6 |
UniProt Entry Name: | STAT6_HUMAN |