Anti-Phospho-STAT4-Y693 pAb Antibody (CABP0781)
- SKU:
- CABP0781
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-Phospho-STAT4-Y693 Antibody |
| 抗体コード: | CABP0781 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic phosphorylated peptide around Y693 of human STAT4 (NP_001230764.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | A synthetic phosphorylated peptide around Y693 of human STAT4 (NP_001230764.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KGYV P |
| 遺伝子ID: | 6775 |
| Uniprot: | Q14765 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 85kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | STAT4, SLEB11 |
| バックグラウンド: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. |
| UniProt Protein Function: | STAT4: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 2q32.2-q32.3 Cellular Component: nucleoplasm; cytoplasm Molecular Function:protein binding; signal transducer activity; sequence-specific DNA binding; transcription factor activity Biological Process: cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; JAK-STAT cascade; protein amino acid phosphorylation Disease: Systemic Lupus Erythematosus, Susceptibility To, 11 |
| NCBI Summary: | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q14765 |
| NCBI GenInfo Identifier: | 6226158 |
| NCBI Gene ID: | 6775 |
| NCBI Accession: | Q14765.1 |
| UniProt Secondary Accession: | Q14765,Q96NZ6, |
| UniProt Related Accession: | Q14765 |
| Molecular Weight: | 85,941 Da |
| NCBI Full Name: | Signal transducer and activator of transcription 4 |
| NCBI Synonym Full Names: | signal transducer and activator of transcription 4 |
| NCBI Official Symbol: | STAT4 |
| NCBI Official Synonym Symbols: | SLEB11 |
| NCBI Protein Information: | signal transducer and activator of transcription 4 |
| UniProt Protein Name: | Signal transducer and activator of transcription 4 |
| Protein Family: | Protein slender lobes |
| UniProt Gene Name: | STAT4 |
| UniProt Entry Name: | STAT4_HUMAN |