Anti-Phospho-RICTOR-T1135 pAb Antibody (CABP0869)
- SKU:
- CABP0869
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
| 抗体名: | Anti-Phospho-RICTOR-T1135 Antibody |
| 抗体コード: | CABP0869 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic phosphorylated peptide around T1135 of human RICTOR (NP_689969.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | A synthetic phosphorylated peptide around T1135 of human RICTOR (NP_689969.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TLTE P |
| 遺伝子ID: | 253260 |
| Uniprot: | Q6R327 |
| セルラーロケーション: | |
| 計算された分子量: | 28kDa/192kDa/195kDa |
| 観察された分子量: |
| 同義語: | RICTOR, AVO3, PIA, hAVO3 |
| バックグラウンド: | RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Ubiquitin conjugating system; Adaptor/scaffold Chromosomal Location of Human Ortholog: 5p13.1 Cellular Component: cytosol; TORC2 complex Molecular Function:enzyme activator activity; protein binding; protein kinase binding Biological Process: actin cytoskeleton reorganization; embryonic development; establishment and/or maintenance of actin cytoskeleton polarity; establishment of cell polarity; peptidyl-serine phosphorylation; phosphoinositide-mediated signaling; positive regulation of protein kinase B signaling cascade; positive regulation of TOR signaling pathway; regulation of actin cytoskeleton organization and biogenesis; regulation of phosphorylation; regulation of protein kinase B signaling cascade; T cell costimulation |
| NCBI Summary: | RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6R327 |
| NCBI GenInfo Identifier: | 74710068 |
| NCBI Gene ID: | 253260 |
| NCBI Accession: | Q6R327.1 |
| UniProt Secondary Accession: | Q6R327,Q68DT5, Q86UB7, Q8N3A0, Q8NCM6, B2RNX0, B7ZMF7 |
| UniProt Related Accession: | Q6R327 |
| Molecular Weight: | 195,011 Da |
| NCBI Full Name: | Rapamycin-insensitive companion of mTOR |
| NCBI Synonym Full Names: | RPTOR independent companion of MTOR complex 2 |
| NCBI Official Symbol: | RICTOR |
| NCBI Official Synonym Symbols: | PIA; AVO3; hAVO3 |
| NCBI Protein Information: | rapamycin-insensitive companion of mTOR |
| UniProt Protein Name: | Rapamycin-insensitive companion of mTOR |
| UniProt Synonym Protein Names: | AVO3 homolog; hAVO3 |
| Protein Family: | Rapamycin-insensitive companion |
| UniProt Gene Name: | RICTOR |
| UniProt Entry Name: | RICTR_HUMAN |