Anti-Phospho-PPP1CA-T320 pAb Antibody (CABP0786)
- SKU:
- CABP0786
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-Phospho-PPP1CA-T320 Antibody |
抗体コード: | CABP0786 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A phospho specific peptide corresponding to residues surrounding T320 of human PPP1CA |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, NIH/3T3 |
免疫原: | A phospho specific peptide corresponding to residues surrounding T320 of human PPP1CA |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 5499 |
Uniprot: | P62136 |
セルラーロケーション: | Cytoplasm, Nucleus, nucleolus, nucleoplasm |
計算された分子量: | 32kDa/37kDa/38kDa |
観察された分子量: | 38kDa |
同義語: | PPP1CA, PP-1A, PP1A, PP1alpha, PPP1A |
バックグラウンド: | The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | PPP1CA: is a catalytic subunit of protein phosphatase 1 (PP1), aubiquitous cytosolic serine-threonine phosphatase. Composed of a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma. |
UniProt Protein Details: | Protein type:EC 3.1.3.16; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; nuclear chromosome, telomeric region; nucleoplasm; nucleus; plasma membrane Molecular Function:phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein binding Biological Process: circadian regulation of gene expression; dephosphorylation; entrainment of circadian clock by photoperiod; negative regulation of protein binding; protein amino acid dephosphorylation; regulation of circadian rhythm |
NCBI Summary: | The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P62136 |
NCBI GenInfo Identifier: | 49065811 |
NCBI Gene ID: | 5499 |
NCBI Accession: | P62136.1 |
UniProt Secondary Accession: | P62136,P08129, P20653, P22802, Q07161, A6NNR3, B2R908 |
UniProt Related Accession: | P62136 |
Molecular Weight: | Calculated MW: 32kDa/37kDa/38kDaObserved MW: 38kDa |
NCBI Full Name: | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
NCBI Synonym Full Names: | protein phosphatase 1 catalytic subunit alpha |
NCBI Official Symbol: | PPP1CA |
NCBI Official Synonym Symbols: | PP1A; PP-1A; PPP1A; PP1alpha |
NCBI Protein Information: | serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
UniProt Protein Name: | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
Protein Family: | Serine/threonine-protein phosphatase |
UniProt Gene Name: | PPP1CA |