| UniProt Protein Function: | PPP2CA: ubiquitous cytosolic Ser/Thr protein phosphatase, catalytic subunit. The holoenzyme consists of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B'/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. |
| UniProt Protein Details: | Protein type:EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: microtubule cytoskeleton; spindle pole; protein phosphatase type 2A complex; membrane; mitochondrion; plasma membrane; nucleus; cytosol; chromosome, pericentric region Molecular Function:protein dimerization activity; protein C-terminus binding; protein binding; metal ion binding; GABA receptor binding; protein serine/threonine phosphatase activity Biological Process: mitotic nuclear envelope reassembly; apoptosis; regulation of protein amino acid autophosphorylation; protein amino acid dephosphorylation; response to organic substance; regulation of transcription, DNA-dependent; meiotic cell cycle; regulation of cell differentiation; regulation of growth; mesoderm development; regulation of receptor activity; regulation of DNA replication; inactivation of MAPK activity; second-messenger-mediated signaling; regulation of cell adhesion; fibroblast growth factor receptor signaling pathway; RNA splicing; regulation of Wnt receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat3 protein; mRNA catabolic process, nonsense-mediated decay; gene expression; regulation of protein catabolic process; mitotic cell cycle; negative regulation of cell growth; ceramide metabolic process |
| NCBI Summary: | This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P67775 |
| NCBI GenInfo Identifier: | 54038809 |
| NCBI Gene ID: | 5515 |
| NCBI Accession: | P67775.1 |
| UniProt Related Accession: | P67775 |
| Molecular Weight: | |
| NCBI Full Name: | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| NCBI Synonym Full Names: | protein phosphatase 2 catalytic subunit alpha |
| NCBI Official Symbol: | PPP2CA |
| NCBI Official Synonym Symbols: | RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha |
| NCBI Protein Information: | serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| UniProt Synonym Protein Names: | Replication protein C |
| Protein Family: | PP2A regulatory |
| UniProt Gene Name: | PPP2CA |
| UniProt Entry Name: | PP2AA_HUMAN |
