Anti-Phospho-P70S6K1-S424 Antibody (CABP0478)

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SKU:
CABP0478
Product type:
Antibody
Application:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
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Description

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抗体名:Anti-Phospho-P70S6K1-S424 Antibody
抗体コード:CABP0478
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:A phospho specific peptide corresponding to residues surrounding S424 of human P70S6K1
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human
ポジティブサンプル:
免疫原:A phospho specific peptide corresponding to residues surrounding S424 of human P70S6K1
精製方法:Affinity purification
ストレージバッファ:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:6198
Uniprot:P23443
セルラーロケーション:Cell junction, Cytoplasm, Mitochondrion outer membrane, Mitochondrion, Nucleus, synapse, synaptosome
計算された分子量:51kDa/52kDa/56kDa/59kDa
観察された分子量:Refer to figures
同義語:PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha, P70 S6K, RPS6KB1, p70S6KA
バックグラウンド:This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.
UniProt Protein Function:p70S6K: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Translation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; AGC group; RSK family; p70 subfamily

Chromosomal Location of Human Ortholog: 17q23.1

NCBI Summary:This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
UniProt Code:P23443
NCBI GenInfo Identifier:54041234
NCBI Gene ID:6198
NCBI Accession:P23443.2
UniProt Secondary Accession:P23443,Q7Z721, B2R779, B4DLT4, B4DTG1, E7ESB8, F6UYM1
UniProt Related Accession:P23443
Molecular Weight:525
NCBI Full Name:Ribosomal protein S6 kinase beta-1
NCBI Synonym Full Names:ribosomal protein S6 kinase, 70kDa, polypeptide 1
NCBI Official Symbol:RPS6KB1  
NCBI Official Synonym Symbols:S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha  
NCBI Protein Information:ribosomal protein S6 kinase beta-1; p70 S6 kinase, alpha; ribosomal protein S6 kinase I; serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A
UniProt Protein Name:Ribosomal protein S6 kinase beta-1
UniProt Synonym Protein Names:70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA
Protein Family:Ribosomal protein S6 kinase
UniProt Gene Name:RPS6KB1  
UniProt Entry Name:KS6B1_HUMAN
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