| UniProt Protein Function: | MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; TKL group; TKL-Unique family Cellular Component: membrane; cytoplasm; plasma membrane Molecular Function: transferase activity, transferring phosphorus-containing groups; protein complex binding; nucleotide binding; protein kinase binding; ATP binding; protein kinase activity Biological Process: programmed cell death; protein amino acid phosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9D2Y4 |
| NCBI GenInfo Identifier: | 81916976 |
| NCBI Gene ID: | 74568 |
| NCBI Accession: | Q9D2Y4.1 |
| UniProt Secondary Accession: | Q9D2Y4,Q8CIJ5 |
| UniProt Related Accession: | Q9D2Y4 |
| Molecular Weight: | 54kDa |
| NCBI Full Name: | Mixed lineage kinase domain-like protein |
| NCBI Synonym Full Names: | mixed lineage kinase domain-like |
| NCBI Official Symbol: | Mlkl |
| NCBI Official Synonym Symbols: | 9130019I15Rik |
| NCBI Protein Information: | mixed lineage kinase domain-like protein; mlkl |
| UniProt Protein Name: | Mixed lineage kinase domain-like protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Mixed lineage kinase domain-like protein |
| UniProt Gene Name: | Mlkl |
| UniProt Entry Name: | MLKL_MOUSE |
