Anti-Phospho-MKNK1-T197/202 Antibody (CABP0544)
- SKU:
- CABP0544
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-Phospho-MKNK1-T197/202 Antibody |
抗体コード: | CABP0544 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A phospho specific peptide corresponding to residues surrounding T197/202 of human MKNK1 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, NIH/3T3, PC12 |
免疫原: | A phospho specific peptide corresponding to residues surrounding T197/202 of human MKNK1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 8569 |
Uniprot: | Q9BUB5 |
セルラーロケーション: | Cytoplasm, Cytoplasm, Nucleus |
計算された分子量: | 39kDa/47kDa/51kDa |
観察された分子量: | 51kDa |
同義語: | MNK1, MKNK1 |
バックグラウンド: | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. |
UniProt Protein Function: | Mnk1: a CAM kinase of the MAPKKAPK family that can regulate translation. Following activation by MAP kinases, Mnk1 phosphorylates eIF4E at Ser209, increasing its affinity for the 7-methylguanosine-containing mRNA cap. Two MAPK phosphorylation sites in mouse Mnk1 (Thr197 and Thr202) are essential for its kinase activity. Three alternatively spliced human isoforms have been described. |
UniProt Protein Details: | Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Translation; Protein kinase, CAMK; CAMK group; MAPKAPK family; MNK subfamily Chromosomal Location of Human Ortholog: 1p33 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding; protein serine/threonine kinase activity Biological Process: fibroblast growth factor receptor signaling pathway; peptidyl-serine phosphorylation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of translational initiation |
NCBI Summary: | This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012] |
UniProt Code: | Q9BUB5 |
NCBI GenInfo Identifier: | 30316115 |
NCBI Gene ID: | 8569 |
NCBI Accession: | Q9BUB5.1 |
UniProt Secondary Accession: | Q9BUB5,O00312, Q5TC06, Q5TC07, Q6V0N6, D3DQ20, D3DQ21 |
UniProt Related Accession: | Q9BUB5 |
Molecular Weight: | 39,104 Da |
NCBI Full Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
NCBI Synonym Full Names: | MAP kinase interacting serine/threonine kinase 1 |
NCBI Official Symbol: | MKNK1 |
NCBI Official Synonym Symbols: | MNK1 |
NCBI Protein Information: | MAP kinase-interacting serine/threonine-protein kinase 1 |
UniProt Protein Name: | MAP kinase-interacting serine/threonine-protein kinase 1 |
UniProt Synonym Protein Names: | MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1 |
Protein Family: | MAP kinase-interacting serine/threonine-protein kinase |
UniProt Gene Name: | MKNK1 |
UniProt Entry Name: | MKNK1_HUMAN |