Anti-Phospho-MET-Y1234/1235 Antibody (CABP0533)
- SKU:
- CABP0533
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-Phospho-MET-Y1234/1235 Antibody |
抗体コード: | CABP0533 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | A synthetic phosphorylated peptide around Y1234 & Y1235 of human MET (NP_000236.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | HeLa |
免疫原: | A synthetic phosphorylated peptide around Y1234 & Y1235 of human MET (NP_000236.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | EYYS |
遺伝子ID: | 4233 |
Uniprot: | P08581 |
セルラーロケーション: | Membrane, Secreted, Single-pass type I membrane protein |
計算された分子量: | 85kDa/155kDa/157kDa |
観察された分子量: | 156kDa |
同義語: | MET, AUTS9, DFNB97, HGFR, RCCP2, c-Met |
バックグラウンド: | This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. |
UniProt Protein Function: | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis. |
NCBI Summary: | This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016] |
UniProt Code: | P08581 |
NCBI GenInfo Identifier: | 251757497 |
NCBI Gene ID: | 4233 |
NCBI Accession: | P08581.4 |
UniProt Secondary Accession: | P08581,O60366, Q12875, Q9UDX7, Q9UPL8, A1L467, B5A932 E7EQ94, |
UniProt Related Accession: | P08581 |
Molecular Weight: | 85,745 Da |
NCBI Full Name: | Hepatocyte growth factor receptor |
NCBI Synonym Full Names: | MET proto-oncogene, receptor tyrosine kinase |
NCBI Official Symbol: | MET |
NCBI Official Synonym Symbols: | HGFR; AUTS9; RCCP2; c-Met; DFNB97 |
NCBI Protein Information: | hepatocyte growth factor receptor |
UniProt Protein Name: | Hepatocyte growth factor receptor |
UniProt Synonym Protein Names: | HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met |
Protein Family: | C-methyltransferase |
UniProt Gene Name: | MET |