| UniProt Protein Function: | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. |
| NCBI Summary: | The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43561 |
| NCBI GenInfo Identifier: | 14194891 |
| NCBI Gene ID: | 27040 |
| NCBI Accession: | O43561.1 |
| UniProt Secondary Accession: | O43561,O43919, B7WPI0, C7C5T6, G5E9K3, |
| UniProt Related Accession: | O43561 |
| Molecular Weight: | 27,774 Da |
| NCBI Full Name: | Linker for activation of T-cells family member 1 |
| NCBI Synonym Full Names: | linker for activation of T-cells |
| NCBI Official Symbol: | LAT |
| NCBI Official Synonym Symbols: | LAT1; pp36 |
| NCBI Protein Information: | linker for activation of T-cells family member 1 |
| UniProt Protein Name: | Linker for activation of T-cells family member 1 |
| UniProt Synonym Protein Names: | 36 kDa phospho-tyrosine adapter protein; pp36; p36-38 |
| Protein Family: | Latexin |
| UniProt Gene Name: | LAT |
| UniProt Entry Name: | LAT_HUMAN |
