Anti-Phospho-IRE1-S724 Antibody (CABP1146)
- SKU:
- CABP1146
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
抗体名: | Anti-Phospho-IRE1-S724 Antibody |
抗体コード: | CABP1146 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A phospho specific peptide corresponding to residues surrounding S724 of human IRE1 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa |
免疫原: | A phospho specific peptide corresponding to residues surrounding S724 of human IRE1 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 2081 |
Uniprot: | O75460 |
セルラーロケーション: | Endoplasmic reticulum membrane, Single-pass type I membrane protein |
計算された分子量: | 110kDa |
観察された分子量: | 130KDa |
同義語: | IRE1, IRE1P, IRE1a, hIRE1p |
バックグラウンド: | The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008] |
NCBI Summary: | This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017] |
UniProt Code: | O75460 |
NCBI GenInfo Identifier: | 193806335 |
NCBI Gene ID: | 2081 |
NCBI Accession: | O75460.2 |
UniProt Secondary Accession: | O75460,Q76MJ5, |
UniProt Related Accession: | O75460 |
Molecular Weight: | Observed: 110 kDaPredicted: 110 kDa |
NCBI Full Name: | Serine/threonine-protein kinase/endoribonuclease IRE1 |
NCBI Synonym Full Names: | endoplasmic reticulum to nucleus signaling 1 |
NCBI Official Symbol: | ERN1 |
NCBI Official Synonym Symbols: | IRE1; IRE1P; IRE1a; hIRE1p |
NCBI Protein Information: | serine/threonine-protein kinase/endoribonuclease IRE1 |
UniProt Protein Name: | Serine/threonine-protein kinase/endoribonuclease IRE1 |
UniProt Synonym Protein Names: | Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a |
Protein Family: | Serine/threonine-protein kinase/endoribonuclease |
UniProt Gene Name: | ERN1 |
UniProt Entry Name: | ERN1_HUMAN |