Anti-Phospho-IKKEpsilon-S172 Antibody (CABP1127)
- SKU:
- CABP1127
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| 抗体名: | Anti-Phospho-IKKEpsilon-S172 Antibody |
| 抗体コード: | CABP1127 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S172 of human IKK?. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S172 of human IKK?. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 9641 |
| Uniprot: | Q14164 |
| セルラーロケーション: | Cytoplasm, Nucleus, PML body |
| 計算された分子量: | 70kDa/80kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | IKBKE, IKK-E, IKK-i, IKKE, IKKI, inhibitor of nuclear factor kappa-B kinase subunit epsilon |
| バックグラウンド: | IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] |
| UniProt Protein Function: | IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel. |
| UniProt Protein Details: | Protein type:Inhibitor; Kinase, protein; EC 2.7.11.10; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family Chromosomal Location of Human Ortholog: 1q32.1 Cellular Component: nucleoplasm; PML body; cytoplasm; mitochondrial membrane; endosome membrane; nucleus; cytosol Molecular Function:NF-kappaB-inducing kinase activity; protein binding; IkappaB kinase activity; ATP binding Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; DNA damage response, signal transduction resulting in induction of apoptosis; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; toll-like receptor 3 signaling pathway; I-kappaB phosphorylation; negative regulation of interferon type I production; toll-like receptor 4 signaling pathway; protein amino acid phosphorylation |
| NCBI Summary: | IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] |
| UniProt Code: | Q14164 |
| NCBI GenInfo Identifier: | 14548079 |
| NCBI Gene ID: | 9641 |
| NCBI Accession: | Q14164.1 |
| UniProt Secondary Accession: | Q14164,Q3B754, Q3KR43, Q5JTS6, D3DT78, |
| UniProt Related Accession: | Q14164 |
| Molecular Weight: | 716 |
| NCBI Full Name: | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
| NCBI Synonym Full Names: | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon |
| NCBI Official Symbol: | IKBKE |
| NCBI Official Synonym Symbols: | IKKE; IKKI; IKK-E; IKK-i |
| NCBI Protein Information: | inhibitor of nuclear factor kappa-B kinase subunit epsilon; IKK-epsilon; I-kappa-B kinase epsilon; inducible IkappaB kinase; IKK-related kinase epsilon; inducible I kappa-B kinase |
| UniProt Protein Name: | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
| UniProt Synonym Protein Names: | Inducible I kappa-B kinase; IKK-i |
| UniProt Gene Name: | IKBKE |
| UniProt Entry Name: | IKKE_HUMAN |