Anti-Phospho-IKKbeta-Y199 抗体

Anti-Phospho-IKKbeta-Y199 Antibody (CABP1237)

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SKU:

CABP1237

Product type:

Antibody

Antibody Type:

Polyclonal Antibody

Reactivity:

Human

Reactivity:

Mouse

Reactivity:

Rat

Host Species:

Rabbit

Isotype:

IgG

Synonyms:

IKBKB

Synonyms:

IKK-beta

Synonyms:

IKK2

Synonyms:

IKKB

Synonyms:

IMD15

Synonyms:

NFKBIKB

Synonyms:

IKK beta

Description

Description

UniProt Protein Function:	IKKB: a kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Preferentially found as a heterodimer with IKK-alpha but also as an homodimer.
UniProt Protein Details:	Protein type:Kinase, protein; EC 2.7.11.10; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; IKK family Chromosomal Location of Human Ortholog: 8p11.2 Cellular Component: internal side of plasma membrane; cytoplasm; IkappaB kinase complex; cytosol; nucleus; lipid raft Molecular Function:protein serine/threonine kinase activity; protein binding; protein homodimerization activity; IkappaB kinase activity; protein heterodimerization activity; protein kinase binding; ATP binding; protein kinase activity Biological Process: I-kappaB kinase/NF-kappaB cascade; nerve growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; response to virus; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; serine phosphorylation of STAT protein; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; negative regulation of apoptosis Disease: Immunodeficiency 15
NCBI Summary:	The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:	O14920
NCBI GenInfo Identifier:	14285497
NCBI Gene ID:	3551
NCBI Accession:	O14920.1
UniProt Secondary Accession:	O14920,O75327, B4DZ30, B4E0U4,
UniProt Related Accession:	O14920
Molecular Weight:	86,564 Da
NCBI Full Name:	Inhibitor of nuclear factor kappa-B kinase subunit beta
NCBI Synonym Full Names:	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
NCBI Official Symbol:	IKBKB
NCBI Official Synonym Symbols:	IKK2; IKKB; IMD15; NFKBIKB; IKK-beta
NCBI Protein Information:	inhibitor of nuclear factor kappa-B kinase subunit beta; IKK-B; I-kappa-B kinase 2; I-kappa-B-kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta
UniProt Protein Name:	Inhibitor of nuclear factor kappa-B kinase subunit beta
UniProt Synonym Protein Names:	I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta
UniProt Gene Name:	IKBKB
UniProt Entry Name:	IKKB_HUMAN

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