Anti-Phospho-HSP90AB1-S254 Antibody (CABP0203)
- SKU:
- CABP0203
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
抗体名: | Anti-Phospho-HSP90AB1-S254 Antibody |
抗体コード: | CABP0203 |
抗体サイズ: | 100 uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | A phospho specific peptide corresponding to residues surrounding S254 of human Hsp90 beta |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | HeLa |
免疫原: | A phospho specific peptide corresponding to residues surrounding S254 of human Hsp90 beta |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 3326 |
Uniprot: | P08238 |
セルラーロケーション: | Cytoplasm, Melanosome |
計算された分子量: | 83kDa |
観察された分子量: | 83kDa |
同義語: | D6S182, HSP84, HSP90B, HSPC2, HSPCB, Hsp90 beta, HSP90AB1 |
バックグラウンド: | This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. |
UniProt Protein Function: | HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family. |
UniProt Protein Details: | Protein type:Heat shock protein; Chaperone Chromosomal Location of Human Ortholog: 6p12 Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; cell surface; cytoplasm; cytosol; inclusion body; melanosome; membrane; mitochondrion; nucleoplasm; signalosome Molecular Function:ATP binding; dATP binding; double-stranded RNA binding; GTP binding; histone deacetylase binding; kinase binding; nitric-oxide synthase regulator activity; protein binding; protein kinase binding; sulfonylurea receptor binding; TPR domain binding; unfolded protein binding Biological Process: axon guidance; innate immune response; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; placenta development; positive regulation of cell size; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; protein folding; regulation of protein ubiquitination; response to salt stress; response to unfolded protein; virion attachment to host cell surface receptor |
NCBI Summary: | This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012] |
UniProt Code: | P08238 |
NCBI GenInfo Identifier: | 17865718 |
NCBI Gene ID: | 3326 |
NCBI Accession: | P08238.4 |
UniProt Secondary Accession: | P08238,Q5T9W7, Q9NQW0, Q9NTK6, B2R5P0, |
UniProt Related Accession: | P08238 |
Molecular Weight: | 83,264 Da |
NCBI Full Name: | Heat shock protein HSP 90-beta |
NCBI Synonym Full Names: | heat shock protein 90kDa alpha family class B member 1 |
NCBI Official Symbol: | HSP90AB1 |
NCBI Official Synonym Symbols: | HSP84; HSPC2; HSPCB; D6S182; HSP90B |
NCBI Protein Information: | heat shock protein HSP 90-beta |
UniProt Protein Name: | Heat shock protein HSP 90-beta |
UniProt Synonym Protein Names: | Heat shock 84 kDa; HSP 84; HSP84 |
Protein Family: | Heat shock protein |
UniProt Gene Name: | HSP90AB1 |
UniProt Entry Name: | HS90B_HUMAN |