Anti-Phospho-GRIN2B-Y1070 Antibody (CABP0964)
- SKU:
- CABP0964
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| 抗体名: | Anti-Phospho-GRIN2B-Y1070 Antibody |
| 抗体コード: | CABP0964 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A phospho synthetic peptide corresponding to residues surrounding Y1070 of human GRIN2B. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | A phospho synthetic peptide corresponding to residues surrounding Y1070 of human GRIN2B. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 2904 |
| Uniprot: | Q13224 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 166kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | GRIN2B, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, hNR3 |
| バックグラウンド: | This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. |
| UniProt Protein Function: | NMDAR2B: an NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death. |
| UniProt Protein Details: | Protein type:Channel, ligand-gated; Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 12p12 Cellular Component: postsynaptic membrane; synaptic vesicle; neuron projection; cell surface; integral to plasma membrane; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex Molecular Function:protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; glycine binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity Biological Process: synaptic transmission, glutamatergic; axon guidance; startle response; behavioral fear response; in utero embryonic development; glutamate signaling pathway; regulation of synaptic plasticity; learning; memory; synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; behavioral response to pain; sensory organ development; learning and/or memory; response to ethanol; suckling behavior; transport; ionotropic glutamate receptor signaling pathway; ephrin receptor signaling pathway; regulation of excitatory postsynaptic membrane potential Disease: Mental Retardation, Autosomal Dominant 6; Epileptic Encephalopathy, Early Infantile, 27 |
| NCBI Summary: | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13224 |
| NCBI GenInfo Identifier: | 14548162 |
| NCBI Gene ID: | 2904 |
| NCBI Accession: | Q13224.3 |
| UniProt Secondary Accession: | Q13224,Q12919, Q13220, Q13225, Q14CU4, Q9UM56, |
| UniProt Related Accession: | Q13224 |
| Molecular Weight: | 1484 |
| NCBI Full Name: | Glutamate receptor ionotropic, NMDA 2B |
| NCBI Synonym Full Names: | glutamate receptor, ionotropic, N-methyl D-aspartate 2B |
| NCBI Official Symbol: | GRIN2B |
| NCBI Official Synonym Symbols: | MRD6; NR2B; hNR3; EIEE27; GluN2B; NMDAR2B |
| NCBI Protein Information: | glutamate receptor ionotropic, NMDA 2B; NR3; glutamate receptor subunit epsilon-2; N-methyl-D-aspartate receptor subunit 3; N-methyl D-aspartate receptor subtype 2B; glutamate [NMDA] receptor subunit epsilon-2 |
| UniProt Protein Name: | Glutamate receptor ionotropic, NMDA 2B |
| UniProt Synonym Protein Names: | Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NR2B; N-methyl-D-aspartate receptor subunit 3; NR3; hNR3 |
| Protein Family: | Glutamate receptor ionotropic |
| UniProt Gene Name: | GRIN2B |
| UniProt Entry Name: | NMDE2_HUMAN |