| UniProt Protein Function: | Fyn: a tyrosine kinase of the Src family. Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Three alternatively spliced isoforms have been described. Isoform 2 shows a greater ability to mobilize cytoplasmic calcium than isoform 1. Induced expression aids in cellular transformation and xenograft metastasis. In squamous cell carcinoma, Fyn transduces signals from EGFR and Src and is required for cell migration and invasiveness. Activity linked to migration in a murine melanoma model. Appears to block late stage development of neuroblastoma. Mouse knockout deficient in kindling response, a model for human epilepsy. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, TK; Oncoprotein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); TK group; Src family Chromosomal Location of Human Ortholog: 6q21 Cellular Component: cytosol; endosome; extrinsic to internal side of plasma membrane; lipid raft; plasma membrane Molecular Function:ephrin receptor binding; glycoprotein binding; non-membrane spanning protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity Biological Process: axon guidance; blood coagulation; cell differentiation; cell migration; central nervous system development; ephrin receptor signaling pathway; feeding behavior; innate immune response; learning; leukocyte migration; MAPKKK cascade; peptidyl-tyrosine phosphorylation; phosphoinositide-mediated signaling; platelet activation; regulation of apoptosis; regulation of cell proliferation; regulation of defense response to virus by virus; regulation of phosphoinositide 3-kinase cascade; stimulatory C-type lectin receptor signaling pathway; T cell activation; T cell costimulation; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P06241 |
| NCBI GenInfo Identifier: | 125370 |
| NCBI Gene ID: | 2534 |
| NCBI Accession: | P06241.3 |
| UniProt Secondary Accession: | P06241,Q16248, Q5R3A6, Q5R3A7, Q8N5D7, B5BU57, E1P557 H0UI48, |
| UniProt Related Accession: | P06241 |
| Molecular Weight: | 54,513 Da |
| NCBI Full Name: | Tyrosine-protein kinase Fyn |
| NCBI Synonym Full Names: | FYN proto-oncogene, Src family tyrosine kinase |
| NCBI Official Symbol: | FYN |
| NCBI Official Synonym Symbols: | SLK; SYN; p59-FYN |
| NCBI Protein Information: | tyrosine-protein kinase Fyn |
| UniProt Protein Name: | Tyrosine-protein kinase Fyn |
| UniProt Synonym Protein Names: | Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn |
| Protein Family: | FYN-binding protein |
| UniProt Gene Name: | FYN |
| UniProt Entry Name: | FYN_HUMAN |
