Anti-Phospho-FANCG-S383 pAb Antibody (CABP0833)
- SKU:
- CABP0833
- Product type:
- Antibody
- Application:
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-Phospho-FANCG-S383 Antibody |
| 抗体コード: | CABP0833 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic phosphorylated peptide around S383 of human FANCG (NP_004620.1). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | A synthetic phosphorylated peptide around S383 of human FANCG (NP_004620.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RFSP P |
| 遺伝子ID: | 2189 |
| Uniprot: | O15287 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 68kDa |
| 観察された分子量: |
 | Immunofluorescence analysis of U2OS cells using Phospho-FANCG-S383 antibody (CABP0833) at dilution of 1:100. Blue: DAPI for nuclear staining. |
| 同義語: | FANCG, FAG, XRCC9 |
| バックグラウンド: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. |
| UniProt Protein Function: | FANCG: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene. Defects in FANCG are a cause of Fanconi anemia complementation group G (FANCG). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
| UniProt Protein Details: | Protein type:DNA repair, damage Chromosomal Location of Human Ortholog: 9p13 Cellular Component: cytoplasm; mitochondrion; nucleolus; nucleoplasm; plasma membrane Molecular Function:damaged DNA binding; protein binding Biological Process: cell cycle checkpoint; DNA repair; mitochondrion organization and biogenesis Disease: Fanconi Anemia, Complementation Group G; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
| NCBI Summary: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15287 |
| NCBI GenInfo Identifier: | 6136453 |
| NCBI Gene ID: | 2189 |
| NCBI Accession: | O15287.1 |
| UniProt Related Accession: | O15287 |
| Molecular Weight: | 68,554 Da |
| NCBI Full Name: | Fanconi anemia group G protein |
| NCBI Synonym Full Names: | Fanconi anemia complementation group G |
| NCBI Official Symbol: | FANCG |
| NCBI Official Synonym Symbols: | FAG; XRCC9 |
| NCBI Protein Information: | Fanconi anemia group G protein |
| UniProt Protein Name: | Fanconi anemia group G protein |
| UniProt Synonym Protein Names: | DNA repair protein XRCC9 |
| Protein Family: | Fanconi anemia group G protein |
| UniProt Gene Name: | FANCG |
| UniProt Entry Name: | FANCG_HUMAN |