Anti-Phospho-EEF2-T56 pAb Antibody (CABP0832)
- SKU:
- CABP0832
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
抗体名: | Anti-Phospho-EEF2-T56 Antibody |
抗体コード: | CABP0832 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic phosphorylated peptide around T56 of human EEF2 (NP_001952.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | NIH/3T3, C6 |
免疫原: | A synthetic phosphorylated peptide around T56 of human EEF2 (NP_001952.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TRFT D |
遺伝子ID: | 1938 |
Uniprot: | P13639 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 95kDa |
観察された分子量: | 105kDa |
同義語: | EEF2, EEF-2, EF-2, EF2, SCA26 |
バックグラウンド: | This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. |
UniProt Protein Function: | EEF2: a member of the GTP-binding translation elongation factor family. An essential factor for protein synthesis. Promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by eEF2 kinase phosphorylation. eEF2 kinase is normally dependent on Ca2+ ions and calmodulin. eEF2 kinase can also be activated by PKA in response to elevated cAMP levels, which are generally increased in stress- or starvation-related conditions. A variety of treatments known to raise intracellular Ca2+ or cAMP levels have been shown to result in increased phosphorylation of eEF2, and thus to inhibit peptide-chain elongation. |
UniProt Protein Details: | Protein type:Translation elongation; Translation Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: polysome; membrane; cytoplasm; plasma membrane; cytosol; ribonucleoprotein complex; nucleus Molecular Function:GTPase activity; protein binding; GTP binding; protein kinase binding; translation elongation factor activity Biological Process: translational elongation; cellular protein metabolic process; translation; positive regulation of translation; peptidyl-diphthamide biosynthetic process from peptidyl-histidine; pathogenesis; hemopoietic progenitor cell differentiation; gene expression; post-translational protein modification Disease: Spinocerebellar Ataxia 26 |
NCBI Summary: | This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008] |
UniProt Code: | P13639 |
NCBI GenInfo Identifier: | 119172 |
NCBI Gene ID: | 1938 |
NCBI Accession: | P13639.4 |
UniProt Secondary Accession: | P13639,Q58J86, B2RMP5, D6W618, |
UniProt Related Accession: | P13639 |
Molecular Weight: | 858 |
NCBI Full Name: | Elongation factor 2 |
NCBI Synonym Full Names: | eukaryotic translation elongation factor 2 |
NCBI Official Symbol: | EEF2 |
NCBI Official Synonym Symbols: | EF2; EF-2; EEF-2; SCA26 |
NCBI Protein Information: | elongation factor 2; polypeptidyl-tRNA translocase |
UniProt Protein Name: | Elongation factor 2 |
Protein Family: | Elongation factor |
UniProt Gene Name: | EEF2 |
UniProt Entry Name: | EF2_HUMAN |