Anti-Phospho-Crk p38-Y221 Antibody (CABP1150)
- SKU:
- CABP1150
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-Phospho-Crk p38-Y221 Antibody |
| 抗体コード: | CABP1150 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding Y221 of human Crk p38 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | NIH/3T3, C6 |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding Y221 of human Crk p38 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 1398 |
| Uniprot: | P46108 |
| セルラーロケーション: | |
| 計算された分子量: | 34kDa |
| 観察された分子量: | 34KDa |
 | Western blot - Phospho-Crk p38-Y221 Rabbit mAb (CABP1150) |
| 同義語: | CRKII, p38 |
| バックグラウンド: | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | CRK: an adaptor protein with an SH2-SH3-SH3 domain structure. Recruits cytoplasmic proteins through SH2-phospho-tyrosine interaction. Phosphorylated by Abl, IGF-IR and EGFR. Phosphorylation induces a change in intramolecular folding and SH2 interactions, causing its rapid dissociation from the tyrosine kinase complex. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold; Oncoprotein Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus; actin cytoskeleton Molecular Function:protein phosphorylated amino acid binding; protein binding; ephrin receptor binding; SH3/SH2 adaptor activity; SH2 domain binding Biological Process: regulation of transcription from RNA polymerase II promoter; regulation of Rac protein signal transduction; platelet activation; activation of MAPKK activity; nerve growth factor receptor signaling pathway; regulation of actin cytoskeleton organization and biogenesis; insulin receptor signaling pathway; ephrin receptor signaling pathway; innate immune response; vascular endothelial growth factor receptor signaling pathway; blood coagulation |
| NCBI Summary: | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P46108 |
| NCBI GenInfo Identifier: | 158939322 |
| NCBI Gene ID: | 1398 |
| NCBI Accession: | P46108.2 |
| UniProt Secondary Accession: | P46108,Q96GA9, Q96HJ0, A8MWE8, B0LPE8, D3DTH6, |
| UniProt Related Accession: | P46108 |
| Molecular Weight: | 304 |
| NCBI Full Name: | Adapter molecule crk |
| NCBI Synonym Full Names: | v-crk avian sarcoma virus CT10 oncogene homolog |
| NCBI Official Symbol: | CRK |
| NCBI Official Synonym Symbols: | p38; CRKII |
| NCBI Protein Information: | adapter molecule crk; proto-oncogene c-Crk |
| UniProt Protein Name: | Adapter molecule crk |
| UniProt Synonym Protein Names: | Proto-oncogene c-Crk; p38 |
| Protein Family: | Crk-like protein |
| UniProt Gene Name: | CRK |
| UniProt Entry Name: | CRK_HUMAN |