Anti-Phospho-CDC25A-S76 Antibody (CABP1166)
- SKU:
- CABP1166
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-Phospho-CDC25A-S76 Antibody |
| 抗体コード: | CABP1166 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S76 of human CDC25A |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | NIH/3T3 |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding S76 of human CDC25A |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 993 |
| Uniprot: | P30304 |
| セルラーロケーション: | |
| 計算された分子量: | 54kDa/59kDa |
| 観察された分子量: | 59kDa |
 | Western blot - Phospho-CDC25A-S76 Rabbit pAb (CABP1166) |
| 同義語: | CDC25A, CDC25A2 |
| バックグラウンド: | CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CDC25A: a member of the MPI phosphatase family. Functions as a dosage-dependent inducer in mitotic control. Required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein phosphatase, dual-specificity; EC 3.1.3.48; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3p21 Cellular Component: nucleoplasm; cytosol Molecular Function:protein binding; protein tyrosine phosphatase activity; protein kinase binding Biological Process: cell proliferation; mitosis; response to radiation; cell division; regulation of cell cycle; mitotic cell cycle; regulation of cyclin-dependent protein kinase activity; DNA replication; G2/M transition of mitotic cell cycle; G1/S transition of mitotic cell cycle |
| NCBI Summary: | CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30304 |
| NCBI GenInfo Identifier: | 50403734 |
| NCBI Gene ID: | 993 |
| NCBI Accession: | P30304.2 |
| UniProt Secondary Accession: | P30304,Q8IZH5, Q96IL3, Q9H2F2, |
| UniProt Related Accession: | P30304 |
| Molecular Weight: | |
| NCBI Full Name: | M-phase inducer phosphatase 1 |
| NCBI Synonym Full Names: | cell division cycle 25A |
| NCBI Official Symbol: | CDC25A |
| NCBI Official Synonym Symbols: | CDC25A2 |
| NCBI Protein Information: | M-phase inducer phosphatase 1; CDC25A2-CAG isoform; CDC25 isoform A1-CAG; dual specificity phosphatase CDC25A |
| UniProt Protein Name: | M-phase inducer phosphatase 1 |
| UniProt Synonym Protein Names: | Dual specificity phosphatase Cdc25A |
| Protein Family: | M-phase inducer phosphatase |
| UniProt Gene Name: | CDC25A |
| UniProt Entry Name: | MPIP1_HUMAN |