Anti-Phospho-Camk2a-T286 Antibody (CABP0255)
- SKU:
- CABP0255
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-Phospho-Camk2a-T286 Antibody |
| 抗体コード: | CABP0255 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding T286 of human Camk2a |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse brain |
| 免疫原: | A phospho specific peptide corresponding to residues surrounding T286 of human Camk2a |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 815 |
| Uniprot: | Q9UQM7 |
| セルラーロケーション: | Cell junction, presynaptic cell membrane, synapse |
| 計算された分子量: | 22kDa/54kDa |
| 観察された分子量: | 54kDa |
 | Western blot analysis of extracts of mouse brain, using Phospho-CAMK2A-T286 antibody (CABP0255) at 1:1000 dilution. Mouse brain cell lysates were treated by CIP at 37†’†’€š°C for 1 hour. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% BSA. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | CAMK2A, CAMKA |
| バックグラウンド: | The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, CAMK; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; CAMK2 family Chromosomal Location of Human Ortholog: 5q32 Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus; plasma membrane Molecular Function:calmodulin binding; glutamate receptor binding; kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; Ras guanyl-nucleotide exchange factor activity Biological Process: activation of NF-kappaB transcription factor; calcium ion transport; G1/S transition of mitotic cell cycle; MAPKKK cascade; peptidyl-serine phosphorylation; positive regulation of calcium ion transport; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; Wnt receptor signaling pathway, calcium modulating pathway |
| NCBI Summary: | The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q9UQM7 |
| NCBI GenInfo Identifier: | 296434552 |
| NCBI Gene ID: | 815 |
| NCBI Accession: | Q9UQM7.2 |
| UniProt Secondary Accession: | Q9UQM7,Q9UL21, Q9Y2H4, Q9Y352, |
| UniProt Related Accession: | Q9UQM7 |
| Molecular Weight: | 55,320 Da |
| NCBI Full Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
| NCBI Synonym Full Names: | calcium/calmodulin dependent protein kinase II alpha |
| NCBI Official Symbol: | CAMK2A |
| NCBI Official Synonym Symbols: | CAMKA |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase type II subunit alpha |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
| Protein Family: | Calcium/calmodulin-dependent protein kinase |
| UniProt Gene Name: | CAMK2A |
| UniProt Entry Name: | KCC2A_HUMAN |