| UniProt Protein Function: | ARHGEF2: a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. Mediates cross-talk between microtubules and the actin cytoskeleton. Contains a phorbol esters/diacylglycerol binding and PH domain. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs Chromosomal Location of Human Ortholog: 1q21-q22 Cellular Component: cell soma; cytoplasm; cytoplasmic membrane-bound vesicle; cytoskeleton; cytosol; dendritic shaft; focal adhesion; Golgi apparatus; microtubule; protein complex; spindle; tight junction; vesicle Molecular Function:microtubule binding; protein binding; Rac GTPase binding; Rac guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity; transcription factor binding; zinc ion binding Biological Process: actin filament organization; activation of NF-kappaB transcription factor; cell division; cell morphogenesis; establishment of mitotic spindle orientation; innate immune response; intracellular protein transport; mitosis; negative regulation of microtubule depolymerization; negative regulation of neurogenesis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of GTPase activity; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; regulation of cell proliferation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction |
| NCBI Summary: | Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009] |
| UniProt Code: | Q92974 |
| NCBI GenInfo Identifier: | 205830906 |
| NCBI Gene ID: | 9181 |
| NCBI Accession: | Q92974.4 |
| UniProt Secondary Accession: | Q92974,O75142, Q15079, Q5VY92, Q8TDA3, Q8WUG4, Q9H023 D3DVA6, |
| UniProt Related Accession: | Q92974 |
| Molecular Weight: | 108,242 Da |
| NCBI Full Name: | Rho guanine nucleotide exchange factor 2 |
| NCBI Synonym Full Names: | Rho/Rac guanine nucleotide exchange factor 2 |
| NCBI Official Symbol: | ARHGEF2 |
| NCBI Official Synonym Symbols: | GEF; P40; GEFH1; LFP40; GEF-H1 |
| NCBI Protein Information: | rho guanine nucleotide exchange factor 2 |
| UniProt Protein Name: | Rho guanine nucleotide exchange factor 2 |
| UniProt Synonym Protein Names: | Guanine nucleotide exchange factor H1; GEF-H1; Microtubule-regulated Rho-GEF; Proliferating cell nucleolar antigen p40 |
| Protein Family: | Rho guanine nucleotide exchange factor |
| UniProt Gene Name: | ARHGEF2 |
| UniProt Entry Name: | ARHG2_HUMAN |
