Anti-PHLPP2 Antibody (CAB18218)
- SKU:
- CAB18218
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
抗体名: | Anti-PHLPP2 Antibody |
抗体コード: | CAB18218 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human PHLPP2. |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse eye, Rat eye |
免疫原: | Recombinant protein of human PHLPP2. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 23035 |
Uniprot: | Q6ZVD8 |
セルラーロケーション: | |
計算された分子量: | 147kDa |
観察された分子量: | 140kDa |
同義語: | PHLPP2, PHLPPL, PPM3B |
バックグラウンド: |
UniProt Protein Function: | PHLPP2: Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser- 657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Tumor suppressor; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 16q22.2 Cellular Component: cytoplasm; cytosol |
UniProt Code: | Q6ZVD8 |
NCBI GenInfo Identifier: | 116242711 |
NCBI Gene ID: | 23035 |
NCBI Accession: | Q6ZVD8.3 |
UniProt Secondary Accession: | Q6ZVD8,Q9NV17, Q9Y2E3, A1L374, |
UniProt Related Accession: | Q6ZVD8 |
Molecular Weight: | 139,394 Da |
NCBI Full Name: | PH domain leucine-rich repeat-containing protein phosphatase 2 |
NCBI Synonym Full Names: | PH domain and leucine rich repeat protein phosphatase 2 |
NCBI Official Symbol: | PHLPP2 |
NCBI Official Synonym Symbols: | PPM3B; PHLPPL |
NCBI Protein Information: | PH domain leucine-rich repeat-containing protein phosphatase 2 |
UniProt Protein Name: | PH domain leucine-rich repeat-containing protein phosphatase 2 |
UniProt Synonym Protein Names: | PH domain leucine-rich repeat-containing protein phosphatase-like; PHLPP-like |
Protein Family: | PH domain leucine-rich repeat-containing protein phosphatase |
UniProt Gene Name: | PHLPP2 |
UniProt Entry Name: | PHLP2_HUMAN |