| バックグラウンド: | This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. |
| UniProt Protein Function: | PHLDA2: a protein may play a role in regulating placenta growth. Contains one PH domain. Expressed in placenta and adult prostate gland. Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 11p15.4 Biological Process: apoptosis |
| NCBI Summary: | This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q53GA4 |
| NCBI GenInfo Identifier: | 84029394 |
| NCBI Gene ID: | 7262 |
| NCBI Accession: | Q53GA4.2 |
| UniProt Secondary Accession: | Q53GA4,O00496, |
| UniProt Related Accession: | Q53GA4 |
| Molecular Weight: | 17,092 Da |
| NCBI Full Name: | Pleckstrin homology-like domain family A member 2 |
| NCBI Synonym Full Names: | pleckstrin homology like domain family A member 2 |
| NCBI Official Symbol: | PHLDA2 |
| NCBI Official Synonym Symbols: | IPL; BRW1C; BWR1C; HLDA2; TSSC3 |
| NCBI Protein Information: | pleckstrin homology-like domain family A member 2 |
| UniProt Protein Name: | Pleckstrin homology-like domain family A member 2 |
| UniProt Synonym Protein Names: | Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; Imprinted in placenta and liver protein; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; p17-Beckwith-Wiedemann region 1 C; p17-BWR1C |
| Protein Family: | Pleckstrin homology-like domain family |
| UniProt Gene Name: | PHLDA2 |
| UniProt Entry Name: | PHLA2_HUMAN |
